| Peroxisomes are signaling platforms for antiviral innate immunity. | |
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MedLine Citation:
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PMID: 20451243 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Peroxisomes have long been established to play a central role in regulating various metabolic activities in mammalian cells. These organelles act in concert with mitochondria to control the metabolism of lipids and reactive oxygen species. However, while mitochondria have emerged as an important site of antiviral signal transduction, a role for peroxisomes in immune defense is unknown. Here, we report that the RIG-I-like receptor (RLR) adaptor protein MAVS is located on peroxisomes and mitochondria. We find that peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. The interferon regulatory factor IRF1 plays a crucial role in regulating MAVS-dependent signaling from peroxisomes. These results establish that peroxisomes are an important site of antiviral signal transduction. |
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Authors:
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Evelyn Dixit; Steeve Boulant; Yijing Zhang; Amy S Y Lee; Charlotte Odendall; Bennett Shum; Nir Hacohen; Zhijian J Chen; Sean P Whelan; Marc Fransen; Max L Nibert; Giulio Superti-Furga; Jonathan C Kagan |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-05-06 |
Journal Detail:
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Title: Cell Volume: 141 ISSN: 1097-4172 ISO Abbreviation: Cell Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-18 Completed Date: 2010-05-20 Revised Date: 2011-03-16 |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: United States |
Other Details:
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Languages: eng Pagination: 668-81 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Division of Gastroenterology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GEO/GSE21215 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptor Proteins, Signal Transducing
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immunology,
metabolism Animals Cell Line Cercopithecus aethiops Fibroblasts / metabolism Hepatocytes / metabolism Humans Immunity, Innate* Interferons / metabolism Mice Mitochondria / metabolism Peroxisomes / metabolism* Signal Transduction* Vero Cells |
| Grant Support | |
ID/Acronym/Agency:
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AI059371/AI/NIAID NIH HHS; R01 AI059371-06/AI/NIAID NIH HHS; R01 AI059371-07/AI/NIAID NIH HHS; //Howard Hughes Medical Institute |
| Chemical | |
Reg. No./Substance:
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0/Adaptor Proteins, Signal Transducing; 0/IPS-1 protein, mouse; 0/VISA protein, human; 9008-11-1/Interferons |
| Comments/Corrections | |
Comment In:
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Cell. 2010 May 14;141(4):570-2
[PMID:
20478250
]
Nat Rev Immunol. 2010 Jul;10(7):465 [PMID: 20586123 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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