Document Detail


Peroxisome proliferator-activated receptors in the cardiovascular system.
MedLine Citation:
PMID:  10696077     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Peroxisome proliferator-activated receptor (PPAR)s are a family of three nuclear hormone receptors, PPARalpha, -delta, and -gamma, which are members of the steriod receptor superfamily. The first member of the family (PPARalpha) was originally discovered as the mediator by which a number of xenobiotic drugs cause peroxisome proliferation in the liver. Defined functions for all these receptors, until recently, mainly concerned their ability to regulate energy balance, with PPARalpha being involved in beta-oxidation pathways, and PPARgamma in the differentiation of adipocytes. Little is known about the functions of PPARdelta, though it is the most ubiquitously expressed. Since their discovery, PPARs have been shown to be expressed in monocytes/macrophages, the heart, vascular smooth muscle cells, endothelial cells, and in atherosclerotic lesions. Furthermore, PPARs can be activated by a vast number of compounds including synthetic drugs, of the clofibrate, and anti-diabetic thiazoldinedione classes, polyunsaturated fatty acids, and a number of eicosanoids, including prostaglandins, lipoxygenase products, and oxidized low density lipoprotein. This review will aim to introduce the field of PPAR nuclear hormone receptors, and discuss the discovery and actions of PPARs in the cardiovascular system, as well as the source of potential ligands.
Authors:
D Bishop-Bailey
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  British journal of pharmacology     Volume:  129     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-05-04     Completed Date:  2000-05-04     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  823-34     Citation Subset:  IM    
Affiliation:
Vascular Biology Center, Department of Physiology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut, CT 06030-3505, USA. d.bishop-bailey@mds.qmw.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiovascular Diseases / physiopathology
Cardiovascular Physiological Phenomena*
Humans
Receptors, Cytoplasmic and Nuclear / physiology*
Receptors, Retinoic Acid / physiology
Retinoid X Receptors
Transcription Factors / physiology*
Chemical
Reg. No./Substance:
0/Receptors, Cytoplasmic and Nuclear; 0/Receptors, Retinoic Acid; 0/Retinoid X Receptors; 0/Transcription Factors
Comments/Corrections

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