| Peroxisome proliferator activated receptor-γ and the ubiquitin-proteasome system in colorectal cancer. | |
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MedLine Citation:
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PMID: 21160623 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Peroxisome proliferator activated receptor-γ (PPARγ), a transcription factor of the nuclear receptor superfamily plays a significant role in colorectal cancer pathogenesis. In most experimental systems PPARγ activation has tumor suppressing effects in the colon. PPARγ is regulated at multiple levels by the ubiquitin-proteasome system (UPS). At a first level, UPS regulates PPARγ transcription. This regulation involves both PPARγ transcription specific factors and the general transcription machinery. At a second level UPS regulates PPARγ and its co-factors themselves, as PPARγ and many co-factors are proteasome substrates. At a third level of regulation, transduction pathways working in parallel but also having interrelations with PPARγ are regulated by the UPS, creating a network of regulation in the colorectal carcinogenesis-related pathways that are under UPS control. Activation of PPARγ transcription by direct pharmacologic activators and by stabilization of its molecule by proteasome inhibitors could be strategies to be exploited in colorectal cancer treatment. |
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Authors:
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Ioannis A Voutsadakis |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: World journal of gastrointestinal oncology Volume: 2 ISSN: 1948-5204 ISO Abbreviation: World J Gastrointest Oncol Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-12-16 Completed Date: 2011-07-14 Revised Date: 2013-05-29 |
Medline Journal Info:
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Nlm Unique ID: 101532470 Medline TA: World J Gastrointest Oncol Country: China |
Other Details:
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Languages: eng Pagination: 235-41 Citation Subset: - |
Affiliation:
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Ioannis A Voutsadakis, Department of Medical Oncology, University Hospital of Larissa, Larissa 41110, Greece. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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