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Peroxisome proliferator activated receptor-γ and the ubiquitin-proteasome system in colorectal cancer.
MedLine Citation:
PMID:  21160623     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Peroxisome proliferator activated receptor-γ (PPARγ), a transcription factor of the nuclear receptor superfamily plays a significant role in colorectal cancer pathogenesis. In most experimental systems PPARγ activation has tumor suppressing effects in the colon. PPARγ is regulated at multiple levels by the ubiquitin-proteasome system (UPS). At a first level, UPS regulates PPARγ transcription. This regulation involves both PPARγ transcription specific factors and the general transcription machinery. At a second level UPS regulates PPARγ and its co-factors themselves, as PPARγ and many co-factors are proteasome substrates. At a third level of regulation, transduction pathways working in parallel but also having interrelations with PPARγ are regulated by the UPS, creating a network of regulation in the colorectal carcinogenesis-related pathways that are under UPS control. Activation of PPARγ transcription by direct pharmacologic activators and by stabilization of its molecule by proteasome inhibitors could be strategies to be exploited in colorectal cancer treatment.
Authors:
Ioannis A Voutsadakis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of gastrointestinal oncology     Volume:  2     ISSN:  1948-5204     ISO Abbreviation:  World J Gastrointest Oncol     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-12-16     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101532470     Medline TA:  World J Gastrointest Oncol     Country:  China    
Other Details:
Languages:  eng     Pagination:  235-41     Citation Subset:  -    
Affiliation:
Ioannis A Voutsadakis, Department of Medical Oncology, University Hospital of Larissa, Larissa 41110, Greece.
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