Document Detail


Peroxisome proliferator-activated receptor gamma ligands suppress liver carcinogenesis induced by diethylnitrosamine in rats.
MedLine Citation:
PMID:  15526359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: Peroxisome proliferator-activated receptor gamma (PPARgamma) is known to regulate growth arrest and terminal differentiation of adipocytes and is used clinically as a new class of antidiabetic drugs. Recently, several studies have reported that treatment of cancer cells with PPARgamma ligands could induce cell differentiation and apoptosis, suggesting a potential application as chemopreventive agents against carcinogenesis. In the present study, 3 different kinds of PPARgamma ligands were subjected to the experiments to confirm their suppressive effects on liver carcinogenesis. METHODS: Three PPARgamma ligands, pioglitazone (Pio) (200 ppm), rosiglitazone (Rosi) (200 ppm), and troglitazone (Tro) (1,000 ppm) were investigated on the induction of the placental form of rat glutathione S-transferase (rGST P) positive foci, a precancerous lesion of the liver, and liver cancer formation using a diethylnitrosamine-induced liver cancer model in Wistar rats, and dose dependency of a PPARgamma ligand was also examined. RESULTS: PPARgamma ligands reduced the formation of rGST P-positive foci by diethylnitrosamine and induction of liver cancers was also markedly suppressed by a continuous feeding of Pio at 200 ppm. CONCLUSION: PPARgamma ligands are potential chemopreventive agents for liver carcinogenesis.
Authors:
Yan-Tong Guo; Xi-Sheng Leng; Tao Li; Jing-Ming Zhao; Xi-Hou Lin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  10     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-04     Completed Date:  2005-01-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  3419-23     Citation Subset:  IM    
Affiliation:
Department of General Surgery, Beijing Jishuitan Hospital, the Forth Clinical Medical College of Peking University, Beijing 100035, China. guoyantong2002@sohu.com
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MeSH Terms
Descriptor/Qualifier:
Alkylating Agents
Animals
Anticarcinogenic Agents / metabolism,  pharmacology*
Chromans / metabolism,  pharmacology
Diethylnitrosamine
Gene Expression
Glutathione Transferase / metabolism
Hypoglycemic Agents / metabolism,  pharmacology*
Immunohistochemistry
Ligands
Liver Neoplasms / chemically induced,  metabolism,  prevention & control*
Male
PPAR gamma / genetics,  metabolism*
RNA, Messenger / analysis
Rats
Rats, Wistar
Thiazolidinediones / metabolism,  pharmacology*
Chemical
Reg. No./Substance:
0/Alkylating Agents; 0/Anticarcinogenic Agents; 0/Chromans; 0/Hypoglycemic Agents; 0/Ligands; 0/PPAR gamma; 0/RNA, Messenger; 0/Thiazolidinediones; 111025-46-8/pioglitazone; 122320-73-4/rosiglitazone; 55-18-5/Diethylnitrosamine; 97322-87-7/troglitazone; EC 2.5.1.18/Glutathione Transferase

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