| Peroxisome proliferator-activated receptor-gamma coactivator-1 gene locus: associations with hypertension in middle-aged men. | |
| | |
MedLine Citation:
|
PMID: 12574109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Peroxisome proliferator-activated receptor-gamma coactivator-1 (PPARGC1/PGC-1) is a transcriptional coactivator of nuclear hormone receptors implicated in blood pressure regulation. We therefore ascertained whether the PPARGC1 gene locus is associated with hypertension. We studied associations of 3 polymorphisms in PPARGC1 transcripts with hypertension in 683 middle-aged men and 530 middle-aged women of a cross-sectional Austrian population. Hypertension was defined by average values of systolic or diastolic ambulatory blood pressure readings (taken between 7 AM and 10 PM) above 140 and/or 90 and/or use of antihypertensive medication. Among the 3 polymorphic sites, genotype distributions associated with Gly482Ser differed by hypertension status in men (P=0.0038), but not in women. The less common Ser482 allele was associated with a modest, but significant, reduction in the prevalence of hypertension in men. The distribution of 3 loci haplotypes also differed in men with and without hypertension (P=0.015). Despite its moderate effect, but because of its high frequency (approximately 64%), the more common risk allele contributed to hypertension in 35% (95% CI 16% to 54%) of our male population. These results suggest, but do not prove, that PPARGC1 participates in blood pressure control, and sequence substitutions at its gene locus confer an increased risk of hypertension to a substantial proportion of men. |
| | |
Authors:
|
Hannes Oberkofler; Bertram Hölzl; Harald Esterbauer; Mingqiang Xie; Bernhard Iglseder; Franz Krempler; Bernhard Paulweber; Wolfgang Patsch |
Related Documents
:
|
9794739 - Influence of cardiovascular risk factors on relation between angiotensin converting enz... 9039079 - Absence of linkage for "endothelial" nitric oxide synthase locus to blood pressure in d... 10745099 - Pressurization facilitates adenovirus-mediated gene transfer into vein graft. 18971529 - Genetic variations of cyp2c9 in 724 japanese individuals and their impact on the antihy... 20739939 - A46g and c79g polymorphisms in the β2-adrenergic receptor gene (adrb2) and essential h... 17275579 - Inherited renal tubulopathies associated with metabolic alkalosis: effects on blood pre... 1836029 - Raised circulating plasma levels of atrial natriuretic peptide in adolescent and adult ... 9661539 - The hemodynamic effects of hypoxemia in anesthetized pigs: a comparison between right h... 10218619 - Protective effects of ischemic preconditioning on lung ischemia reperfusion injury: an ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Hypertension Volume: 41 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2003 Feb |
Date Detail:
|
Created Date: 2003-02-07 Completed Date: 2003-03-10 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
|
Languages: eng Pagination: 368-72 Citation Subset: IM |
Affiliation:
|
Department of Laboratory Medicine, Landeskliniken, Salzburg, Austria. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Amino Acid Substitution Blood Pressure / physiology Body Mass Index Cross-Sectional Studies Female Genotype Haplotypes Humans Hypertension / genetics*, physiopathology Male Middle Aged Polymorphism, Genetic Polymorphism, Single Nucleotide Risk Factors Sex Factors Statistics as Topic Transcription Factors / genetics* |
| Chemical | |
Reg. No./Substance:
|
0/Transcription Factors; 0/peroxisome-proliferator-activated receptor-gamma coactivator-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Beta(2)-adrenergic receptor gene polymorphism, age, and cardiovascular phenotypes.
Next Document: Regression of hypertensive myocardial fibrosis by Na(+)/H(+) exchange inhibition.