Document Detail


Peroxisome proliferator-activated receptor agonists in a battle against the ageing kidney.
MedLine Citation:
PMID:  24503003     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
As ageing is a complex phenomenon characterized by intraindividual and interindividual diversities in the maintenance of the homeostatic condition of cells and tissues, changes in renal function are not uniform and depend on associated diseases and environmental factors. Multiple studies have investigated the possible underlying mechanisms of age-related decline in kidney function. Evolutionary, molecular, cellular and systemic theories have been postulated to explain the primarily disease independent age-related changes and adaptive responses. As peroxisome proliferator-activated receptors (PPARs) are involved in a broad spectrum of biological processes, PPAR activation might have an effect on the prevention of cell senescence. In this review, we will focus on the experimental and clinical evidence of PPAR agonists in a battle against the ageing kidney.
Authors:
Marijn M Speeckaert; Céline Vanfraechem; Reinhart Speeckaert; Joris R Delanghe
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Publication Detail:
Type:  REVIEW     Date:  2014-2-3
Journal Detail:
Title:  Ageing research reviews     Volume:  -     ISSN:  1872-9649     ISO Abbreviation:  Ageing Res. Rev.     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-2-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128963     Medline TA:  Ageing Res Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier B.V.
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