Document Detail

Peroxisome proliferation, wound-activated responses and expression of peroxisome-associated genes are cross-regulated but uncoupled in Arabidopsis thaliana.
MedLine Citation:
PMID:  18194426     Owner:  NLM     Status:  MEDLINE    
Plant peroxisomes are multifunctional organelles that show plasticity in number, size, morphology, cellular location and metabolic functions. Many of these changes occur in response to environmental factors and are decisive for the development and defence of the plant. Among them, peroxisomal beta-oxidation-mediated synthesis of jasmonic acid (JA) is a key process in regulating development as well as wound- or pathogen-triggered defence responses. This work seeks for the connection between wound, JA and the proliferation of peroxisomes in Arabidopsis thaliana. The hypolipidemic drug clofibrate (CFB) induced the proliferation of peroxisomes and the expression of the beta-oxidation 3-ketoacyl-CoA thiolase 2 (KAT2) gene, coding for a key enzyme in the biosynthesis of JA, among other wound- and JA-responsive gene transcripts in Arabidopsis leaves. The CFB-activated expression of wound-responsive genes was not dependent on JA synthesis or perception and those responsive to JA required the function of the F-box protein COI1. In turn, wounding neither triggered peroxisome proliferation nor required peroxisome integrity to activate gene expression. Interestingly, cells from JA-treated leaves contained fewer but larger peroxisomes than cells from untreated leaves. The proliferation of peroxisomes, the synthesis of JA and the activation of wound-responsive genes by CFB, although functionally connected, were uncoupled in Arabidopsis.
Mari Cruz Castillo; Luisa María Sandalio; Luís Alfonso Del Río; José León
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-01-09
Journal Detail:
Title:  Plant, cell & environment     Volume:  31     ISSN:  1365-3040     ISO Abbreviation:  Plant Cell Environ.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-18     Completed Date:  2008-05-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9309004     Medline TA:  Plant Cell Environ     Country:  United States    
Other Details:
Languages:  eng     Pagination:  492-505     Citation Subset:  IM    
Instituto de Biología Molecular y Celular de Plantas (CSIC-UPV), Ciudad Politécnica de la Innovación, 46022 Valencia, Spain.
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MeSH Terms
Arabidopsis / drug effects,  genetics*,  metabolism*
Arabidopsis Proteins / genetics,  metabolism*
Clofibrate / pharmacology
Cyclopentanes / pharmacology
Dose-Response Relationship, Drug
Gene Expression Regulation, Plant / drug effects,  genetics*
Oxylipins / pharmacology
Peroxisomes / genetics*,  physiology*
Plant Growth Regulators / pharmacology
Plant Leaves / drug effects,  ultrastructure
Time Factors
Reg. No./Substance:
0/Arabidopsis Proteins; 0/Cyclopentanes; 0/Oxylipins; 0/Plant Growth Regulators; 637-07-0/Clofibrate; 6894-38-8/jasmonic acid

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