Document Detail


Peroxisome assembly and functional diversity in eukaryotic microorganisms.
MedLine Citation:
PMID:  22994494     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Peroxisomes are core eukaryotic organelles that generally function in lipid metabolism and detoxification of reactive oxygen species, but they are increasingly associated with taxa-specific metabolic, cellular, and developmental functions. Here, we present a brief overview of peroxisome assembly, followed by a discussion of their functional diversification. Matrix protein import occurs through a remarkable translocon that can accommodate folded and even oligomeric proteins. Metabolically specialized peroxisomes include glycosomes of trypanosomes, which have come to compartmentalize most of the glycolytic pathway and play a role in developmental signal transduction. The differentiation of physically distinct subcompartments also contributes to peroxisome diversification; in the clade of filamentous ascomycetes, dense-core Woronin bodies bud from peroxisomes to gate cell-to-cell channels. Here, the import of oligomeric cargo is central to the mechanism of subcompartment specification. In general, the acquisition of a tripeptide peroxisome targeting signal by nonperoxisomal proteins appears to be a recurrent step in the evolution of peroxisome diversity.
Authors:
Laurent Pieuchot; Gregory Jedd
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Annual review of microbiology     Volume:  66     ISSN:  1545-3251     ISO Abbreviation:  Annu. Rev. Microbiol.     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-21     Completed Date:  2013-01-30     Revised Date:  2014-04-04    
Medline Journal Info:
Nlm Unique ID:  0372370     Medline TA:  Annu Rev Microbiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  237-63     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Eukaryota
Metabolic Networks and Pathways
Peroxisomes / metabolism*
Signal Transduction

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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