| Peroxisome assembly and functional diversity in eukaryotic microorganisms. | |
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MedLine Citation:
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PMID: 22994494 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Peroxisomes are core eukaryotic organelles that generally function in lipid metabolism and detoxification of reactive oxygen species, but they are increasingly associated with taxa-specific metabolic, cellular, and developmental functions. Here, we present a brief overview of peroxisome assembly, followed by a discussion of their functional diversification. Matrix protein import occurs through a remarkable translocon that can accommodate folded and even oligomeric proteins. Metabolically specialized peroxisomes include glycosomes of trypanosomes, which have come to compartmentalize most of the glycolytic pathway and play a role in developmental signal transduction. The differentiation of physically distinct subcompartments also contributes to peroxisome diversification; in the clade of filamentous ascomycetes, dense-core Woronin bodies bud from peroxisomes to gate cell-to-cell channels. Here, the import of oligomeric cargo is central to the mechanism of subcompartment specification. In general, the acquisition of a tripeptide peroxisome targeting signal by nonperoxisomal proteins appears to be a recurrent step in the evolution of peroxisome diversity. |
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Authors:
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Laurent Pieuchot; Gregory Jedd |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annual review of microbiology Volume: 66 ISSN: 1545-3251 ISO Abbreviation: Annu. Rev. Microbiol. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-09-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372370 Medline TA: Annu Rev Microbiol Country: United States |
Other Details:
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Languages: eng Pagination: 237-63 Citation Subset: IM |
Affiliation:
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Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, 117604 Singapore; email: laurent@tll.org.sg , gregory@tll.org.sg. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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