Document Detail


Peroxisome proliferator-activated receptor (PPAR) agonists as promising new medications for drug addiction: preclinical evidence.
MedLine Citation:
PMID:  23614675     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This review examines the growing literature on the role of peroxisome proliferator-activated receptors (PPARs) in addiction. There are two subtypes of PPAR receptors that have been studied in addiction: PPAR-α and PPAR-γ. The role of each PPAR subtype in common models of addictive behavior, mainly pre-clinical models, is summarized. In particular, studies are reviewed that investigated the effects of PPAR-α agonists on relapse, sensitization, conditioned place preference, withdrawal and drug intake, and effects of PPAR-γ agonists on relapse, withdrawal and drug intake. Finally, studies that investigated the effects of PPAR agonists on neural pathways of addiction are reviewed. Taken together these preclinical data indicate that PPAR agonists are promising new medications for drug addiction treatment.
Authors:
Bernard Le Foll; Patricia Di Ciano; Leigh V Panlilio; Steven R Goldberg; Roberto Ciccocioppo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Review    
Journal Detail:
Title:  Current drug targets     Volume:  14     ISSN:  1873-5592     ISO Abbreviation:  Curr Drug Targets     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-24     Completed Date:  2013-12-27     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  100960531     Medline TA:  Curr Drug Targets     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  768-76     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Drug Design
Drug Evaluation, Preclinical
Humans
PPAR alpha / agonists*,  metabolism
PPAR gamma / agonists*,  metabolism
Recurrence / prevention & control
Substance Withdrawal Syndrome / drug therapy,  physiopathology
Substance-Related Disorders / drug therapy*,  physiopathology
Grant Support
ID/Acronym/Agency:
Z99 DA999999/DA/NIDA NIH HHS; ZIA DA000001-28/DA/NIDA NIH HHS; ZIA DA000003-27/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/PPAR alpha; 0/PPAR gamma
Comments/Corrections

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