Document Detail


Peroxisome proliferator-activated receptor delta (PPARD) genetic variation and type 2 diabetes in middle-aged Chinese women.
MedLine Citation:
PMID:  21834910     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Animal studies have shown that the peroxime proliferator-activated receptor delta (PPARD) gene regulates glucose metabolism and insulin sensitivity. Genetic variation in the PPARD gene might affect physical endurance and has been associated with obesity. We investigated the independent and modifying effect of variants in the PPARD gene with exercise participation and body mass index (BMI) on type 2 diabetes (T2D), using data from a genome-wide association study (GWAS) of middle-aged women living in Shanghai, China, with 1019 T2D cases and 1709 controls. The genotyping was performed using the Affymetrix Genome-Wide Human SNP Array 6.0 platform. Imputation was used to determine missing genotypes. Participation in exercise was assessed by a questionnaire. Anthropometric variables were measured by trained interviewers. The association between polymorphisms and T2D was assessed by logistic regression analyses. The combined effects of polymorphisms in the PPARD gene with exercise participation and BMI on T2D risk was assessed by conducting stratified analysis with exercise participation and BMI categories. No significant associations between PPARD and T2D were found in either genotyped or imputed SNPs and no effect modification between exercise participation and PPARD genetic variation was found, suggesting that PPARD is not a risk factor for T2D in this population.
Authors:
Raquel Villegas; Scott Williams; Yutang Gao; Qiuyin Cai; Honglan Li; Tom Elasy; Hui Cai; Todd Edwards; Yong-Bing Xiang; Wei Zheng; Jirong Long; Xiao Ou Shu
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of human genetics     Volume:  75     ISSN:  1469-1809     ISO Abbreviation:  Ann. Hum. Genet.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-12     Completed Date:  2011-10-03     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  0416661     Medline TA:  Ann Hum Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  621-9     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors Annals of Human Genetics © 2011 Blackwell Publishing Ltd/University College London.
Affiliation:
Vanderbilt Epidemiology Center, Department of Medicine, Nashville, TN 37203-1738, USA. raquel.villegas@vanderbilt.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Asian Continental Ancestry Group / genetics
Body Mass Index*
Diabetes Mellitus, Type 2 / genetics*
Female
Genome-Wide Association Study
Humans
Middle Aged
Motor Activity*
PPAR delta / genetics*
Polymorphism, Single Nucleotide*
Grant Support
ID/Acronym/Agency:
1 UL1RR024975/RR/NCRR NIH HHS; DK58845/DK/NIDDK NIH HHS; HG004399/HG/NHGRI NIH HHS; K01 DK082639/DK/NIDDK NIH HHS; K01 DK082639-01A1/DK/NIDDK NIH HHS; K01 DK082639-02/DK/NIDDK NIH HHS; K01 DK082639-03/DK/NIDDK NIH HHS; K24 DK077875-05/DK/NIDDK NIH HHS; KO1 DK082639/DK/NIDDK NIH HHS; P30 CA68485/CA/NCI NIH HHS; R01 CA118229/CA/NCI NIH HHS; R01 CA118229/CA/NCI NIH HHS; R01CA100374/CA/NCI NIH HHS; R01CA122756/CA/NCI NIH HHS; R01CA124558/CA/NCI NIH HHS; R01CA64277/CA/NCI NIH HHS; R01CA90899/CA/NCI NIH HHS; R01CA92585/CA/NCI NIH HHS; R37CA70867/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/PPAR delta
Comments/Corrections

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