| Peroxisome Proliferator-Activated Receptor-γ Activation Induces 11β-Hydroxysteroid Dehydrogenase Type 1 Activity in Human Alternative Macrophages. | |
| | |
MedLine Citation:
|
PMID: 22207732 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) catalyzes the intracellular reduction of inactive cortisone to active cortisol, the natural ligand activating the glucocorticoid receptor (GR). Peroxisome proliferator- activated receptor-γ (PPARγ) is a nuclear receptor controlling inflammation, lipid metabolism, and the macrophage polarization state. In this study, we investigated the impact of macrophage polarization on the expression and activity of 11β-HSD1 and the role of PPARγ therein. METHODS AND RESULTS: 11β-HSD1 gene expression is higher in proinflammatory M1 and anti-inflammatory M2 macrophages than in resting macrophages, whereas its activity is highest in M2 macrophages. Interestingly, PPARγ activation induces 11β-HSD1 enzyme activity in M2 macrophages but not in resting macrophages or M1 macrophages. Consequently, human M2 macrophages displayed enhanced responsiveness to the 11β-HSD1 substrate cortisone, an effect amplified by PPARγ induction of 11β-HSD1 activity, as illustrated by an increased expression of GR target genes. CONCLUSIONS: Our data identify a positive cross-talk between PPARγ and GR in human M2 macrophages via the induction of 11β-HSD1 expression and activity. |
| | |
Authors:
|
Giulia Chinetti-Gbaguidi; Mohamed Amine Bouhlel; Corinne Copin; Christian Duhem; Bruno Derudas; Bernadette Neve; Benoit Noel; Jerome Eeckhoute; Philippe Lefebvre; Jonathan R Seckl; Bart Staels |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-29 |
Journal Detail:
|
Title: Arteriosclerosis, thrombosis, and vascular biology Volume: - ISSN: 1524-4636 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-30 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9505803 Medline TA: Arterioscler Thromb Vasc Biol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Université Lille Nord de France, Lille, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Regulation of Lipid Droplet Cholesterol Efflux From Macrophage Foam Cells.
Next Document: Prognostic value of "monosomal karyotype" in comparison to "complex aberrant karyotype" in acute mye...