| Peroxisomal proliferator-activated receptor gamma co-activator-1 alpha gene expression increases above the lactate threshold in human skeletal muscle. | |
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MedLine Citation:
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PMID: 22212273 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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AIM: Peroxisomal proliferator-activated receptor gamma co-activator-1 alpha (PGC-1α) plays a role not only as an activator of mitochondrial biogenesis, but also as a suppressor of inflammatory cytokines, which induce chronic diseases. Therefore, increasing PGC-1α expression can be one of the important factors for preventing chronic diseases. PGC-1α expression is activated by adenosine monophosphate-activated protein kinase (AMPK) and cAMP dependent kinase. The activity of these enzymes depends on the exercise intensity. Therefore, this study compared the effects of two different exercise intensities (above lactate threshold (LT) and below LT) with an equal amount of energy expenditure on PGC-1α gene expression in human skeletal muscle. METHODS: Six young men participated in this study. They performed exercise at 120% and 80% LT intensity. The duration of the 120% LT exercise was 60 minutes and the duration of the session performed at 80% LT was calculated to yield equal energy expenditure as the 120% LT intensity exercise. Skeletal muscle was obtained after 1 hour of exercise. RESULTS: The working rate, % peak VO2 and HR during exercise were significantly higher in at 120% LT than at 80% LT. PGC-1α gene expression was not significantly different between control (0.087; 0.026-0.284 (the median; inter quartile range)) and 80% LT (0.171; 0.030-0.484). However, PGC-1α gene expression after 120% LT (0.441; 0.121-4.643) was significantly higher than in the control. CONCLUSION: The findings of this study suggest that PGC-1α gene expression depends on exercise intensity. |
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Authors:
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T Tobina; K Yoshioka; A Hirata; S Mori; A Kiyonaga; H Tanaka |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of sports medicine and physical fitness Volume: 51 ISSN: 0022-4707 ISO Abbreviation: J Sports Med Phys Fitness Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-01-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376337 Medline TA: J Sports Med Phys Fitness Country: Italy |
Other Details:
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Languages: eng Pagination: 683-8 Citation Subset: IM |
Affiliation:
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Faculty of Sports and Health Science, Fukuoka University, Fukuoka, Japan - tobitaku@ck9.so-net.ne.jp. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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