| Peroxisomal fatty acid oxidation is selectively inhibited by phenothiazines in isolated hepatocytes. | |
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MedLine Citation:
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PMID: 6732769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The production of hydrogen peroxide by isolated hepatocytes in response to lauric, palmitic and oleic acids, a measurement of peroxisomal fatty acid oxidation, is inhibited by phenothiazines under conditions in which ketone body production, a measurement of mitochondrial fatty acid oxidation, does not reveal inhibition of mitochondrial activity. This novel finding provides a pharmacological tool for the study of peroxisomal function in whole cells. The mechanism of this effect of phenothiazines, detected in hepatocytes from rats treated with a peroxisome proliferation inducing drug, is not yet known. |
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Authors:
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F Leighton; R Pérsico; C Necochea |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 120 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1984 Apr |
Date Detail:
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Created Date: 1984-06-22 Completed Date: 1984-06-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 505-11 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chlorpromazine / pharmacology Fatty Acids / metabolism* Hydrogen Peroxide / metabolism Ketone Bodies / biosynthesis Lauric Acids / metabolism Liver / ultrastructure* Male Microbodies / drug effects, metabolism* Oleic Acid Oleic Acids / metabolism Oxidation-Reduction Palmitic Acid Palmitic Acids / metabolism Phenothiazines / pharmacology* Rats |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Ketone Bodies; 0/Lauric Acids; 0/Oleic Acids; 0/Palmitic Acids; 0/Phenothiazines; 112-80-1/Oleic Acid; 143-07-7/lauric acid; 50-53-3/Chlorpromazine; 57-10-3/Palmitic Acid; 7722-84-1/Hydrogen Peroxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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