| Peroxisomal beta-oxidation from endogenous substrates. Demonstration through H2O2 production in the unanaesthetized mouse. | |
| | |
MedLine Citation:
|
PMID: 6372785 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A system was developed in which it is possible to detect in vivo changes in hepatic H2O2 production, using a combination of the catalase inhibitor, 3-amino-1,2,4-triazole and methanol. In mice, starvation significantly increases hepatic H2O2 production and plasma non-esterified fatty acid concentrations. Short-term refeeding after a 24 h starvation period brings H2O2 production and plasma non-esterified fatty acid concentration back to normal in 3h. Administration of insulin 24 h after the onset of starvation normalizes H2O2 production in less than 2h and decreases non-esterified fatty acid concentration below normal values. The suppression by insulin of H2O2 production, as well as its coherence with plasma non-esterified fatty acid concentration, indicate that increased H2O2 production in starved mice reflects peroxisomal beta-oxidation. |
| | |
Authors:
|
C Van den Branden; I Kerckaert; F Roels |
Related Documents
:
|
29495 - Relationship between blood ph and potassium and phosphorus during acute metabolic acido... 3115745 - Effect of different intravenous nutrients on metabolic changes in short-term fasted man. 10849575 - Effects of hyperglycaemia and hyperinsulinaemia on plasma amino acid levels in obese su... 19143525 - Effects of genotype and environment on free amino acid levels in wheat grain: implicati... 8972585 - Inhibition of mouse egg chromosome decondensation due to meiotic apparatus derangement ... 11587335 - Determination of phytosiderophores by anion-exchange chromatography with pulsed amperom... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Biochemical journal Volume: 218 ISSN: 0264-6021 ISO Abbreviation: Biochem. J. Publication Date: 1984 Mar |
Date Detail:
|
Created Date: 1984-06-08 Completed Date: 1984-06-08 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 2984726R Medline TA: Biochem J Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 697-702 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amitrole
/
pharmacology Animals Catalase / metabolism Fatty Acids, Nonesterified / blood Hydrogen Peroxide / metabolism* Insulin / pharmacology Liver / drug effects, metabolism* Male Methanol / pharmacology Mice Mice, Inbred BALB C Microbodies / drug effects, metabolism* Oxidation-Reduction Starvation / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Fatty Acids, Nonesterified; 11061-68-0/Insulin; 61-82-5/Amitrole; 67-56-1/Methanol; 7722-84-1/Hydrogen Peroxide; EC 1.11.1.6/Catalase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Isolation of the ST Ent plasmid specific bacteriophage M124.
Next Document: Effect of glucose on the intracellular pH of pancreatic islet cells.