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Peroxiredoxins and sports: new insights on the antioxidative defense.
MedLine Citation:
PMID:  23055024     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Peroxiredoxins (PRDXs) are multifunctional proteins that have recently received much attention. They are part of the endogenous antioxidative capacity and function as efficient scavengers, especially for hydrogen peroxides. Studies show that physical training can induce an upregulation of PRDX isoform contents in the long term. This might help counteract chronic diseases that are causally linked to a high amount of free radicals, e.g., diabetes mellitus. Furthermore, it has been demonstrated that PRDX can overoxidize under pathological conditions during acute exercise. Overoxidized PRDXs could be useful because they act as protective chaperones. Taken together, it can be speculated that physical activity has a positive effect on the PRDX system and thereby prevents cells from free radical-induced damage.
Authors:
Christian Brinkmann; Klara Brixius
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-10
Journal Detail:
Title:  The journal of physiological sciences : JPS     Volume:  -     ISSN:  1880-6562     ISO Abbreviation:  J Physiol Sci     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101262417     Medline TA:  J Physiol Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Molecular and Cellular Sport Medicine, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany, ch.brinkmann@gmx.net.
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