Document Detail

Peroxiredoxins as molecular triage agents, sacrificing themselves to enhance cell survival during a peroxide attack.
MedLine Citation:
PMID:  22325349     Owner:  NLM     Status:  MEDLINE    
In this issue of Molecular Cell, Day et al. (2012) reveal a surprising benefit of peroxiredoxin inactivation at high H(2)O(2), showing that in Schizosaccharomyces pombe turning off peroxide defenses preserves the pool of reduced thioredoxin for repairing proteins vital to survival.
P Andrew Karplus; Leslie B Poole
Related Documents :
8042669 - Novel karyotype in the ullrich-turner syndrome--45,x/46,x,r(x)/46,x, dic(x)--investigat...
18516279 - The morphologies of breast cancer cell lines in three-dimensional assays correlate with...
18360709 - Hdac inhibitors effectively induce cell type-specific differentiation in human glioblas...
1368119 - A novel vero cell line for use as a mammalian host-vector system in serum-free medium.
3756929 - In vitro differentiation and progression of mouse mammary tumor cells.
2902939 - The hut series of 'carcinogen-transformed' human fibroblast cell lines are derived from...
23260869 - Alpha cells come of age.
8756019 - Classification and grading of squamous cell carcinoma of the cervix.
20145019 - Proanthocyanidins inhibit in vitro and in vivo growth of human non-small cell lung canc...
Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Molecular cell     Volume:  45     ISSN:  1097-4164     ISO Abbreviation:  Mol. Cell     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-13     Completed Date:  2012-04-06     Revised Date:  2014-09-16    
Medline Journal Info:
Nlm Unique ID:  9802571     Medline TA:  Mol Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  275-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Hydrogen Peroxide / pharmacology*
Peroxiredoxins / antagonists & inhibitors*
Schizosaccharomyces / enzymology*
Schizosaccharomyces pombe Proteins / antagonists & inhibitors*,  metabolism*
Thioredoxins / metabolism*
Grant Support
Reg. No./Substance:
0/Schizosaccharomyces pombe Proteins; 0/Tpx1 protein, S pombe; 0/Trx1 protein, S pombe; 52500-60-4/Thioredoxins; BBX060AN9V/Hydrogen Peroxide; EC
Comment On:
Mol Cell. 2012 Feb 10;45(3):398-408   [PMID:  22245228 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Fixin' to divide.
Next Document:  hnRNP A1 Proofreads 3' Splice Site Recognition by U2AF.