Document Detail


Peroxiredoxins as molecular triage agents, sacrificing themselves to enhance cell survival during a peroxide attack.
MedLine Citation:
PMID:  22325349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this issue of Molecular Cell, Day et al. (2012) reveal a surprising benefit of peroxiredoxin inactivation at high H(2)O(2), showing that in Schizosaccharomyces pombe turning off peroxide defenses preserves the pool of reduced thioredoxin for repairing proteins vital to survival.
Authors:
P Andrew Karplus; Leslie B Poole
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Molecular cell     Volume:  45     ISSN:  1097-4164     ISO Abbreviation:  Mol. Cell     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-13     Completed Date:  2012-04-06     Revised Date:  2014-09-16    
Medline Journal Info:
Nlm Unique ID:  9802571     Medline TA:  Mol Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  275-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Hydrogen Peroxide / pharmacology*
Peroxiredoxins / antagonists & inhibitors*
Schizosaccharomyces / enzymology*
Schizosaccharomyces pombe Proteins / antagonists & inhibitors*,  metabolism*
Thioredoxins / metabolism*
Grant Support
ID/Acronym/Agency:
R01 GM050389/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Schizosaccharomyces pombe Proteins; 0/Tpx1 protein, S pombe; 0/Trx1 protein, S pombe; 52500-60-4/Thioredoxins; BBX060AN9V/Hydrogen Peroxide; EC 1.11.1.15/Peroxiredoxins
Comments/Corrections
Comment On:
Mol Cell. 2012 Feb 10;45(3):398-408   [PMID:  22245228 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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