| Peroxiredoxin 6 promotes lung cancer cell invasion by inducing urokinase-type plasminogen activator via p38 kinase, phosphoinositide 3-kinase, and Akt. | |
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MedLine Citation:
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PMID: 19937138 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The peroxiredoxin family of peroxidase has six mammalian members (Prx 1-6). Considering their frequent up-regulation in cancer cells, Prxs may contribute to cancer cells' survival in face of oxidative stress. Here, we show that Prx 6 promotes the invasiveness of lung cancer cells, accompanied by an increase in the activity of phosphoinositide 3-kinase (PI3K), the phosphorylation of p38 kinase and Akt, and the protein levels of uPA. Functional studies reveal that these components support Prx 6-induced invasion in the sequence p38 kinase/PI3K, Akt, and uPA. The findings provide a new understanding of the action of Prx 6 in cancer. |
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Authors:
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Seung Bum Lee; Jin-Nyoung Ho; Sung Hwan Yoon; Ga Young Kang; Sang-Gu Hwang; Hong-Duck Um |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-19 |
Journal Detail:
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Title: Molecules and cells Volume: 28 ISSN: 0219-1032 ISO Abbreviation: Mol. Cells Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2010-01-21 Completed Date: 2010-06-11 Revised Date: 2010-06-16 |
Medline Journal Info:
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Nlm Unique ID: 9610936 Medline TA: Mol Cells Country: United States |
Other Details:
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Languages: eng Pagination: 583-8 Citation Subset: IM |
Affiliation:
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Laboratory of Radiation Tumor Physiology, Korea Institute of Radiological and Medical Sciences, Seoul 139-706, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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1-Phosphatidylinositol 3-Kinase
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metabolism* Cell Growth Processes / physiology Cell Line, Tumor Gene Expression Regulation, Neoplastic / physiology Humans Lung Neoplasms / genetics, metabolism*, pathology* Neoplasm Invasiveness / genetics, pathology Oxidative Stress / genetics Peroxiredoxin VI / genetics, metabolism* Proto-Oncogene Proteins c-akt / metabolism RNA, Small Interfering / genetics Signal Transduction / genetics Transgenes / genetics Urokinase-Type Plasminogen Activator / biosynthesis*, genetics p38 Mitogen-Activated Protein Kinases / metabolism |
| Chemical | |
Reg. No./Substance:
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0/RNA, Small Interfering; EC 1.11.1.15/PRDX6 protein, human; EC 1.11.1.15/Peroxiredoxin VI; EC 2.7.1.137/1-Phosphatidylinositol 3-Kinase; EC 2.7.11.1/Proto-Oncogene Proteins c-akt; EC 2.7.11.24/p38 Mitogen-Activated Protein Kinases; EC 3.4.21.73/Urokinase-Type Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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