Document Detail


Peroxide mediates ethanol-induced cytotoxicity in PC12 cells.
MedLine Citation:
PMID:  11182294     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pheochromocytoma (PC12) cell cultures exhibited a loss of cells and increase in intracellular oxidative stress when exposed to ethanol (EtOH) for 24 h. Catalase, an enzyme that hydrolyzes hydrogen peroxide (H(2)O(2)) to O(2) and H(2)O can attenuate EtOH-induced cell loss and oxidative stress in PC12 cells. This study provides the first clear evidence that oxidative stress in the form of elevated intracellular H(2)O(2) is a primary mechanism of EtOH neurotoxicity in PC12 cells.
Authors:
Y Li; D W Walker; M A King
Related Documents :
8223134 - Induction of morphological and enzymic differentiation in rat pheochromocytoma pc12h ce...
11205744 - Differences in early and late responses between neurotrophin-stimulated trka- and trkc-...
15659124 - Melatonin attenuates 1-methyl-4-phenylpyridinium-induced pc12 cell death.
18629654 - Quantitative assessment of neuronal differentiation in three-dimensional collagen gels ...
8573774 - A human oviduct-specific glycoprotein: synthesis, secretion, and localization during th...
25329394 - The ph-responsive pacc transcription factor of aspergillus fumigatus governs epithelial...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Free radical biology & medicine     Volume:  30     ISSN:  0891-5849     ISO Abbreviation:  Free Radic. Biol. Med.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-06-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8709159     Medline TA:  Free Radic Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  389-92     Citation Subset:  IM    
Affiliation:
Department of Neuroscience, University of Florida College of Medicine, Gainesville, FL 32610, USA. Yangxin@ufbi.ufl.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Catalase / metabolism,  pharmacology
Cell Survival / drug effects*
Ethanol / toxicity*
Flow Cytometry
Free Radicals
Hydrogen Peroxide / metabolism,  pharmacology*
Oxidative Stress / drug effects*
PC12 Cells
Rats
Grant Support
ID/Acronym/Agency:
AA00200/AA/NIAAA NIH HHS; T32 AA07561/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
0/Free Radicals; 64-17-5/Ethanol; 7722-84-1/Hydrogen Peroxide; EC 1.11.1.6/Catalase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Antioxidant alpha-lipoic acid and protein turnover in insulin-resistant rat muscle.
Next Document:  Glucans exhibit weak antioxidant activity, but stimulate macrophage free radical activity.