Document Detail

Peroxide mediates ethanol-induced cytotoxicity in PC12 cells.
MedLine Citation:
PMID:  11182294     Owner:  NLM     Status:  MEDLINE    
Pheochromocytoma (PC12) cell cultures exhibited a loss of cells and increase in intracellular oxidative stress when exposed to ethanol (EtOH) for 24 h. Catalase, an enzyme that hydrolyzes hydrogen peroxide (H(2)O(2)) to O(2) and H(2)O can attenuate EtOH-induced cell loss and oxidative stress in PC12 cells. This study provides the first clear evidence that oxidative stress in the form of elevated intracellular H(2)O(2) is a primary mechanism of EtOH neurotoxicity in PC12 cells.
Y Li; D W Walker; M A King
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Free radical biology & medicine     Volume:  30     ISSN:  0891-5849     ISO Abbreviation:  Free Radic. Biol. Med.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-06-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8709159     Medline TA:  Free Radic Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  389-92     Citation Subset:  IM    
Department of Neuroscience, University of Florida College of Medicine, Gainesville, FL 32610, USA.
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MeSH Terms
Catalase / metabolism,  pharmacology
Cell Survival / drug effects*
Ethanol / toxicity*
Flow Cytometry
Free Radicals
Hydrogen Peroxide / metabolism,  pharmacology*
Oxidative Stress / drug effects*
PC12 Cells
Grant Support
Reg. No./Substance:
0/Free Radicals; 64-17-5/Ethanol; 7722-84-1/Hydrogen Peroxide; EC

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