| Peroxidases of trypanosomatids. | |
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MedLine Citation:
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PMID: 18498224 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This article provides an overview about the recent advances in the dissection of the peroxide metabolism of Trypanosomatidae. This family of protozoan organisms comprises the medically relevant parasites Trypanosoma brucei, Trypanosoma cruzi, and Leishmania spp. Over the past 10 years, three major families of peroxidases have been identified in these organisms: (a) 2-cysteine peroxiredoxins, (b) nonselenium glutathione peroxidases, and (c) ascorbate peroxidases. In trypanosomatids, these enzymes display the unique feature of using reducing equivalents derived from trypanothione, a dithiol found exclusively in these protozoa. The electron transfer between trypanothione and the peroxidases is mediated by a redox shuttle, which can either be tryparedoxin, ascorbate, or even glutathione. The preference for the intermediate molecule differs among each peroxidase and so does the specificity for the peroxide substrate. These observations, added to the fact that these peroxidases are distributed throughout different subcellular compartments, point to the existence of an elaborate peroxide metabolism in trypanosomatids. With the completion of the trypanosomatids genome, other molecules displaying peroxidase activity might be added to this list in the future. |
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Authors:
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Helena Castro; Ana M Tomás |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Antioxidants & redox signaling Volume: 10 ISSN: 1557-7716 ISO Abbreviation: Antioxid. Redox Signal. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-07-07 Completed Date: 2008-09-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888899 Medline TA: Antioxid Redox Signal Country: United States |
Other Details:
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Languages: eng Pagination: 1593-606 Citation Subset: IM |
Affiliation:
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Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Glutathione Peroxidase / genetics, metabolism Molecular Sequence Data Peroxidases / genetics, metabolism* Peroxiredoxins / genetics, metabolism Protozoan Proteins / genetics, metabolism* Sequence Homology, Amino Acid Trypanosomatina / enzymology*, genetics, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Protozoan Proteins; EC 1.11.1.-/Peroxidases; EC 1.11.1.11/ascorbate peroxidase; EC 1.11.1.15/Peroxiredoxins; EC 1.11.1.9/Glutathione Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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