| Peroral lynestrenol and arterial disease in mentally retarded women. A case-control study based on autopsy findings. | |
| | |
MedLine Citation:
|
PMID: 3176939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Autopsy findings from 170 non-smoking and mentally retarded women aged 12-51 years were analysed for any epidemiological association between the use of peroral lynestrenol for inducing therapeutic amenorrhea (TA) and arterial disease. Eighty-six women had received lynestrenol continuously for an average of 81 months (range 2-220 months) and the other 84 had not. After exclusion of 6 cases with known risk factors (diabetes, hypertension) predisposing to arterial disease, pathological arterial changes were found in 16 patients, 10 of them belonging to the TA group and 5 to the non-lynestrenol group. The incidence of arterial disease at autopsy at the age of 35 or more was 8/19 in TA patients and 1/15 in non-lynestrenol patients (p = 0.078). The benefits of prolonged TA induced by lynestrenol in this group of patients must be weighed very carefully against the possible risks involved. |
| | |
Authors:
|
K Huovinen; S Autio; J Kaprio |
Related Documents
:
|
12565059 - The potential value of ultrasonic deformation measurement in differentiating regional i... 18760849 - Informative value of clinical research on multislice computed tomography in the diagnos... 7759719 - Referral for coronary artery revascularization procedures after diagnostic coronary ang... 3801079 - A 31-year-old woman with homozygous familial hypercholesterolemia without significant l... 15515789 - Is hughes-stovin syndrome behçet's disease? 1637519 - Diagnostic accuracy of exercise thallium-201 scintigraphy in men with asymptomatic esse... 11032259 - Acute renal failure after redo thoracoabdominal aortic aneurysm repair in a patient wit... 15666609 - Duplex-doppler ultrasonography in the detection of lower extremities deep venous thromb... 3339179 - Tetralogy of fallot with obstruction of the ventricular septal defect: spectrum of echo... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Acta obstetricia et gynecologica Scandinavica Volume: 67 ISSN: 0001-6349 ISO Abbreviation: Acta Obstet Gynecol Scand Publication Date: 1988 |
Date Detail:
|
Created Date: 1988-11-04 Completed Date: 1988-11-04 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370343 Medline TA: Acta Obstet Gynecol Scand Country: SWEDEN |
Other Details:
|
Languages: eng Pagination: 211-4 Citation Subset: IM |
Affiliation:
|
Rinnekoti Institute for the Mentally Retarded, Espoo, Finland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Amenorrhea Arteries / pathology* Autopsy Cardiovascular Diseases / chemically induced*, pathology Child Female Humans Lynestrenol / adverse effects* Mental Retardation / drug therapy, pathology* Middle Aged |
| Chemical | |
Reg. No./Substance:
|
52-76-6/Lynestrenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of epidural vs. general anesthesia on breastfeeding.
Next Document: Pregnancy outcome after metroplasty in women with müllerian anomalies.