Document Detail

Peroral lynestrenol and arterial disease in mentally retarded women. A case-control study based on autopsy findings.
MedLine Citation:
PMID:  3176939     Owner:  NLM     Status:  MEDLINE    
Autopsy findings from 170 non-smoking and mentally retarded women aged 12-51 years were analysed for any epidemiological association between the use of peroral lynestrenol for inducing therapeutic amenorrhea (TA) and arterial disease. Eighty-six women had received lynestrenol continuously for an average of 81 months (range 2-220 months) and the other 84 had not. After exclusion of 6 cases with known risk factors (diabetes, hypertension) predisposing to arterial disease, pathological arterial changes were found in 16 patients, 10 of them belonging to the TA group and 5 to the non-lynestrenol group. The incidence of arterial disease at autopsy at the age of 35 or more was 8/19 in TA patients and 1/15 in non-lynestrenol patients (p = 0.078). The benefits of prolonged TA induced by lynestrenol in this group of patients must be weighed very carefully against the possible risks involved.
K Huovinen; S Autio; J Kaprio
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  67     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  1988  
Date Detail:
Created Date:  1988-11-04     Completed Date:  1988-11-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  211-4     Citation Subset:  IM    
Rinnekoti Institute for the Mentally Retarded, Espoo, Finland.
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MeSH Terms
Arteries / pathology*
Cardiovascular Diseases / chemically induced*,  pathology
Lynestrenol / adverse effects*
Mental Retardation / drug therapy,  pathology*
Middle Aged
Reg. No./Substance:

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