Document Detail

Pernicious anemia: what are the actual diagnosis criteria?
MedLine Citation:
PMID:  21274387     Owner:  NLM     Status:  MEDLINE    
A gastric intrinsic factor output under 200 U/h after pentagastrin stimulation (N > 2000 U/h) is specific for pernicious anemia. The other findings are either variable or non specific. Serum intrinsic factor antibodies, considered as specific in general practice, are present only in half of the patients with pernicious anemia. In their absence, since the disappearance of the Schilling tests, the gastric tubage currently used for the study of gastric acid secretion, is obligatory for the simultaneous study of intrinsic factor output. This study is important to eliminate another disease much more frequent than pernicious anemia, the protein bound to cobalamin malabsorption was observed in achlorhydric simple atrophic gastritis in the presence of intrinsic factor secretion.
Daniel Cattan
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Publication Detail:
Type:  Comment; Letter    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  17     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-28     Completed Date:  2011-07-18     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  543-4     Citation Subset:  IM    
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MeSH Terms
Anemia, Pernicious / diagnosis*
Gastric Mucosa / metabolism
Intrinsic Factor / metabolism*
Middle Aged
Schilling Test
Reg. No./Substance:
9008-12-2/Intrinsic Factor
Comment On:
World J Gastroenterol. 2009 Nov 7;15(41):5121-8   [PMID:  19891010 ]

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