| Pernicious anemia: what are the actual diagnosis criteria? | |
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MedLine Citation:
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PMID: 21274387 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A gastric intrinsic factor output under 200 U/h after pentagastrin stimulation (N > 2000 U/h) is specific for pernicious anemia. The other findings are either variable or non specific. Serum intrinsic factor antibodies, considered as specific in general practice, are present only in half of the patients with pernicious anemia. In their absence, since the disappearance of the Schilling tests, the gastric tubage currently used for the study of gastric acid secretion, is obligatory for the simultaneous study of intrinsic factor output. This study is important to eliminate another disease much more frequent than pernicious anemia, the protein bound to cobalamin malabsorption was observed in achlorhydric simple atrophic gastritis in the presence of intrinsic factor secretion. |
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Authors:
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Daniel Cattan |
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Publication Detail:
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Type: Comment; Letter |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 17 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-28 Completed Date: 2011-07-18 Revised Date: 2011-07-21 |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 543-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Pernicious
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diagnosis* Female Gastric Mucosa / metabolism Humans Intrinsic Factor / metabolism* Middle Aged Schilling Test |
| Chemical | |
Reg. No./Substance:
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9008-12-2/Intrinsic Factor |
| Comments/Corrections | |
Comment On:
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World J Gastroenterol. 2009 Nov 7;15(41):5121-8
[PMID:
19891010
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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