Document Detail

Permutation distribution estimation applied to the comparison of the profile of the activity of two antianginal drugs.
MedLine Citation:
PMID:  8737958     Owner:  NLM     Status:  MEDLINE    
The comparison of the anti-ischemic activity of trimetazidine and propranolol was evaluated by multiple end points (clinical, exercise test, and ambulatory electrocardiogram [ECG] monitoring criteria) in 149 male patients with effort angina who received either trimetazidine 20 mg tid or propranolol 40 mg tid during a period of 3 months. The distribution of the standardized differences between the two treatments for each variable was obtained by a permutation method. The medians (estimation of the actual difference between the two treatments) and the 5, 25, 75 and 95% quantiles were represented on the same diagram for all end points. The pattern of the standardized distribution of the differences showed a similar activity of both drugs on symptoms and nitrates consumption, on exercise tolerance and increase in ischemic threshold at exercise, and on ischemia recorded at ambulatory ECG monitoring. Conversely, only propranolol decreased heart rate and rate pressure product at rest as well as at exercise, underlining the difference in the mode of action of the two drugs. This descriptive technique is an attractive method to evaluate the differences between drugs considering multiple criteria favouring the estimation of these differences together with their variability.
C Harpey; S Coker; P Sellier; J Maccario; J M Détry
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Fundamental & clinical pharmacology     Volume:  10     ISSN:  0767-3981     ISO Abbreviation:  Fundam Clin Pharmacol     Publication Date:  1996  
Date Detail:
Created Date:  1996-12-06     Completed Date:  1996-12-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8710411     Medline TA:  Fundam Clin Pharmacol     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  151-5     Citation Subset:  IM    
LBF, Scientific Direction, Neuilly-sur-Seine, Belgium.
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MeSH Terms
Angina Pectoris / drug therapy*,  physiopathology
Data Interpretation, Statistical
Double-Blind Method
Electrocardiography, Ambulatory
Exercise Tolerance
Middle Aged
Propranolol / therapeutic use*
Trimetazidine / therapeutic use*
Vasodilator Agents / therapeutic use*
Reg. No./Substance:
0/Vasodilator Agents; 5011-34-7/Trimetazidine; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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