Document Detail

Permissive hypercapnia.
MedLine Citation:
PMID:  12481813     Owner:  NLM     Status:  MEDLINE    
There has been increasing recognition that mechanical ventilation can cause acute parenchymal lung injury (ventilator-induced lung injury, or VILI) in addition to the more widely recognized forms of barotrauma. Furthermore, in patients with acute lung injury, this type of injury may cause considerable morbidity and mortality. Subsequently, the goals of mechanical ventilation have been altered to avoid this outcome. In patients with relatively normal lungs who are receiving mechanical ventilation because of neuromuscular dysfunction or impaired conscious level or for short-term postoperative support, maintaining normal blood-gas tensions without risk of VILI is usually easy. In patients with acute asthma, chronic obstructive pulmonary disease, or acute lung injury, however, accepting abnormal blood-gas tensions, particularly an elevated PaCO2 (permissive hypercapnia), to improve survival and reduce complications is frequently necessary. Extensive experience has shown that ventilated patients usually tolerate moderate hypercapnia and frequently some degree of hypoxemia in the absence of shock, anemia, severe cardiac disease, or other contraindications.
Keith G Hickling
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Respiratory care clinics of North America     Volume:  8     ISSN:  1078-5337     ISO Abbreviation:  Respir Care Clin N Am     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-12-16     Completed Date:  2003-01-03     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9612026     Medline TA:  Respir Care Clin N Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  155-69, v     Citation Subset:  IM    
Department of Intensive Care, Gold Coast Hospital, Nerang Street, Southport QLD 4215, Australia.
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MeSH Terms
Blood Gas Analysis
Carbon Dioxide / blood
Hydrogen-Ion Concentration
Hypercapnia / etiology,  physiopathology*
Lung / physiopathology
Lung Diseases / etiology,  physiopathology
Respiration, Artificial / adverse effects
Reg. No./Substance:
124-38-9/Carbon Dioxide

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