Document Detail


Permethrin modulates cholinergic mini-synaptic currents by partially blocking the calcium channel.
MedLine Citation:
PMID:  21251955     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Pyrethroid insecticide modulation of the voltage-gated sodium channel (VGSC) is proposed to underlie their effects on neuronal excitability by inhibiting channel inactivation and increasing channel open time. However, some in vitro evidences indicate that target sites other than VGSCs could contribute to pyrethroid disruption of neuronal activity. Cholinergic excitability in Drosophila, as in other insects and mammals, is important for activity in the central nervous system. The effects of permethrin, a putative calcium antagonist, on calcium current and cholinergic mini-synaptic transmission were investigated in the Drosophila brain. At concentration of 2.5μM, permethrin significantly decreased the calcium current and cholinergic mini-synaptic current. However, the permethrin could not antagonize the calcium current completely. Removal of calcium from the external solution produced a significant decrease of cholinergic mini-synaptic transmission. The results are consistent with the hypothesis that permethrin may modulate cholinergic mini-synaptic currents by partially blocking the calcium channel.
Authors:
Ying Yan; Ying Yang; Jing You; Guangxin Yang; Ye Xu; Naya Huang; Xutian Wang; Dongzhi Ran; Xi Yuan; Ying Jin; Yuting Fan; Jiayao Lei; Weicong Li; Huaiyu Gu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-18
Journal Detail:
Title:  Toxicology letters     Volume:  -     ISSN:  1879-3169     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Ireland Ltd.
Affiliation:
Neuroscience & Cognition Core Facility, Zhongshan Medical School, Sun Yat-sen University, Guangzhou 510080, China.
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