Document Detail


Permethrin absorption not detected in single-pass perfused rabbit ear, and absorption with oxidation of 3-phenoxybenzyl alcohol.
MedLine Citation:
PMID:  9049055     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Isolated rabbit ears were single-pass perfused with a protein-free medium. Permethrin (0.05-23.5%, w/w) was applied in four distinct ointments. Permethrin, 3-phenoxybenzyl alcohol, 3-phenoxybenzaldehyde, and 3-phenoxybenzoic acid were analysed by HPLC. Permethrin was not detected in the effluent. The permeation coefficient, calculated from the detection limit was < 7.3 x 10(-12) (cm/sec). The appearance rate of the 3-phenoxybenzyl moieties in the effluent agreed with the absorption of the corresponding impurities in the various ointments. In supernatant of homogenised skin, the hydrolysis rate of permethrin was linear; about 4 pmol/min per cm2 at 10 microM substrate concentration. The proportion of 3-phenoxybenzoic acid, a further metabolite of 3-phenoxybenzyl alcohol increased when an oxidizing co-factor system was added. The appearance rate in the effusate of 3-phenoxybenzyl alcohol following the lipophobic ointment was five times faster than from isopropyl myristate. The formation rate of 3-phenoxybenzoic acid followed saturation kinetics. Occupational systemic poisoning by dermal absorption of permethrin seems very unlikely since humans bear more epithelial cell layers than rabbits. These experiments do not contradict, however, possible paraesthesia during systemic poisoning after inhalation or ingestion of the pyrethroid-containing aerosols used in agriculture.
Authors:
G E Bast; D Taeschner; H G Kampffmeyer
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Archives of toxicology     Volume:  71     ISSN:  0340-5761     ISO Abbreviation:  Arch. Toxicol.     Publication Date:  1997  
Date Detail:
Created Date:  1997-05-15     Completed Date:  1997-05-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417615     Medline TA:  Arch Toxicol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  179-86     Citation Subset:  IM    
Affiliation:
Walther-Straub-Institute for Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Benzyl Alcohols / chemistry,  pharmacology*
Chinchilla
Chromatography, High Pressure Liquid
Ear, External / metabolism
Hydrolysis
Insecticides / chemistry,  pharmacokinetics*
Oxidation-Reduction
Perfusion
Permethrin
Pyrethrins / chemistry,  pharmacokinetics*
Rabbits
Skin Absorption / drug effects,  physiology*
Chemical
Reg. No./Substance:
0/Benzyl Alcohols; 0/Insecticides; 0/Pyrethrins; 13826-35-2/3-phenoxybenzylalcohol; 52645-53-1/Permethrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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