Document Detail


Permeation of hyaluronan tetrasaccharides through hairless mouse skin: an in vitro and in vivo study.
MedLine Citation:
PMID:  22740084     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Hyaluronan (HA) is a well-known active ingredient for cosmetic and drug applications. However, based on its varying molecular size, HA may have limited skin permeation. Therefore, the aim of the present study was to investigate the in vitro skin permeability of HA tetrasaccharide (HA4). In addition, the effects of HA4 on in vivo skin barrier function were examined. The cumulative amounts of HA4 through stratum corneum (SC)-stripped skin and full-thickness skin after 8 h were 2,109.6 and 0.8 μg/cm(2), respectively. Furthermore, the cumulative amounts of HA4 permeated after 8 h were 784.4 ng/cm(2) for a HA4 solution with a pH 4 and 70.0 ng/cm(2) with a pH 7 on full-thickness skin. Next, the in vivo effects of HA4 on the water content of the SC and transepidermal water loss (TEWL) were investigated. The dorsal skins of hairless mice were irradiated to a UVA dose of 22.3 J/cm(2)/d, 5 times a week. In the control group, the water content of the SC was decreased and TEWL and epidermal thickness were increased with UVA irradiation than the normal group. However, the water content of the SC was increased in the HA4 group than that of the control group in the non-UVA irradiation groups. In addition, the water content of the SC was increased and TEWL and epidermal thickness were decreased in the HA4 group than those of the control and HA groups. These results suggest that treatment with HA4 improved skin functional recovery after UVA irradiation by skin penetration of HA4.
Authors:
Madoka Kage; Yoshihiro Tokudome; Fumie Hashimoto
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-28
Journal Detail:
Title:  Archives of dermatological research     Volume:  -     ISSN:  1432-069X     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000462     Medline TA:  Arch Dermatol Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama, 350-0295, Japan.
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