| Permeation of human plasma lipoproteins in human carotid endarterectomy tissues: Measurement by optical Coherence tomography. | |
| | |
MedLine Citation:
|
PMID: 21508256 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Atherosclerosis is an inflammatory process occurring in arterial tissue, involving the subintimal accumulation of low-density lipoproteins (LDL). Measurement of the rate at which LDL and other lipoproteins such as high-density lipoprotein (HDL) and very low-density lipoprotein (VLDL) enter and exit the tissue can provide insight into the mechanisms involved in the development of atherosclerotic lesions. Permeation of VLDL, LDL, HDL, and glucose was measured for normal and atherosclerotic human carotid endarterectomy tissues (CEA) at 20°C and 37°C using optical coherence tomography (OCT). The rates for LDL permeation through normal CEA tissue at 20°C was (3.16 ± 0.37) ×10(-5) cm/s and at 37°C was (4.77 ± 0.48) ×10(-5) cm/s, significantly greater (p<0.05) than the rates for atherosclerotic CEA tissue at these temperatures ({(1.97 ± 0.34) × 10(-5) cm/s} and {(2.01 ± 0.23) × 10(-5) cm/s}, respectively). This study effectively uses OCT to measure the rates at which naturally occurring lipoproteins enter normal and diseased carotid intimal tissue. |
| | |
Authors:
|
Mohamad G Ghosn; Maleeha Mashiatulla; Saba H Syed; Mohamed A Mohamed; Kirill V Larin; Joel D Morrisett |
Related Documents
:
|
21489276 - Atp-binding cassette transporter a1 gene polymorphisms and serum lipid levels in young ... 10758366 - Influence of fiber fermentability on nutrient digestion in the dog. 834146 - The effects of two dietary fiber supplements on gastrointestinal transit, stool weight ... 12325116 - Digesta passage and fiber digestibility in captive white-faced sakis (pithecia pithecia). 15271656 - Leptin action is modified by an interaction between dietary fat content and ambient tem... 18344296 - Effects of dried distillers grains with solubles on growing and finishing pig performan... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-4-20 |
Journal Detail:
|
Title: Journal of lipid research Volume: - ISSN: 0022-2275 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-4-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Baylor College of Medicine, United States; |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Filipin recognizes both GM1 and cholesterol in GM1 gangliosidosis mouse brain.
Next Document: IL-23 Receptor Regulation by Let-7f in Human CD4+ Memory T Cells.