| Permeability of bilayers composed of mixtures of saturated phospholipids. | |
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MedLine Citation:
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PMID: 7139845 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Liposomes composed of an equimolar binary mixture of phospholipids were from a series of saturated phosphatidylcholines (PC) and phosphatidylethanolamines (PE). Mixtures were chosen such that the two phospholipids differed either in terms of head group alone, chain length alone, or both head group and chain length. Cation effluxes, both with and without ionophores (nigericin and valinomycin) were measured over a range of temperatures that encompassed the regions of phase separation for these different lipid mixtures. There was a good correlation between the temperatures at which permeability maxima and phase separation occur. For phospholipid mixtures with the same acyl chain but different head groups (PC vs. PE), the PC component 'controls' permeability. For mixtures of PCs differing in chain length, the short chain lipid dominates the permeability pattern particularly if the chain length are sufficiently different. Lipids differing in both head group and chain length give rise to more complex permeability patterns. The results of the present study are interpreted in terms of a model in which one of the lipid components of the mixture may specifically congregate at defects between co-existing phases and thus 'regulate' permeability. |
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Authors:
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M Singer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chemistry and physics of lipids Volume: 31 ISSN: 0009-3084 ISO Abbreviation: Chem. Phys. Lipids Publication Date: 1982 Oct |
Date Detail:
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Created Date: 1983-01-27 Completed Date: 1983-01-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0067206 Medline TA: Chem Phys Lipids Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 145-59 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Liposomes* Nigericin Permeability Phosphatidylcholines Phosphatidylethanolamines Phospholipids* Rubidium* Sodium* Surface Properties Temperature Valinomycin |
| Chemical | |
Reg. No./Substance:
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0/Liposomes; 0/Phosphatidylcholines; 0/Phosphatidylethanolamines; 0/Phospholipids; 2001-95-8/Valinomycin; 28380-24-7/Nigericin; 7440-17-7/Rubidium; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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