Document Detail

Permeability of bilayers composed of mixtures of saturated phospholipids.
MedLine Citation:
PMID:  7139845     Owner:  NLM     Status:  MEDLINE    
Liposomes composed of an equimolar binary mixture of phospholipids were from a series of saturated phosphatidylcholines (PC) and phosphatidylethanolamines (PE). Mixtures were chosen such that the two phospholipids differed either in terms of head group alone, chain length alone, or both head group and chain length. Cation effluxes, both with and without ionophores (nigericin and valinomycin) were measured over a range of temperatures that encompassed the regions of phase separation for these different lipid mixtures. There was a good correlation between the temperatures at which permeability maxima and phase separation occur. For phospholipid mixtures with the same acyl chain but different head groups (PC vs. PE), the PC component 'controls' permeability. For mixtures of PCs differing in chain length, the short chain lipid dominates the permeability pattern particularly if the chain length are sufficiently different. Lipids differing in both head group and chain length give rise to more complex permeability patterns. The results of the present study are interpreted in terms of a model in which one of the lipid components of the mixture may specifically congregate at defects between co-existing phases and thus 'regulate' permeability.
M Singer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemistry and physics of lipids     Volume:  31     ISSN:  0009-3084     ISO Abbreviation:  Chem. Phys. Lipids     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1983-01-27     Completed Date:  1983-01-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0067206     Medline TA:  Chem Phys Lipids     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  145-59     Citation Subset:  IM    
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MeSH Terms
Surface Properties
Reg. No./Substance:
0/Liposomes; 0/Phosphatidylcholines; 0/Phosphatidylethanolamines; 0/Phospholipids; 2001-95-8/Valinomycin; 28380-24-7/Nigericin; 7440-17-7/Rubidium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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