| Permeability and Micromechanical Properties of Silk Ionomer Microcapsules. | |
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MedLine Citation:
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PMID: 22834790 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We studied pH-responsive behavior of the layer-by-layer (LbL) microcapsules fabricated from silk fibroin chemically modified with different poly-amino acid side chains: cationic (silk-poly L-lysine, SF-PL) or anionic (silk-poly-L-glutamic acid, SF-PG). We observed that stable ultrathin shell microcapsules can be assembled with dramatic increase in swelling, thickness and microroughness at extremely acidic (pH﹤2.5) and basic (pH﹥11.0) conditions without noticeable disintegration. These changes are accompanied dramatic changes in shell permeability with a two orders of magnitude increase in the diffusion coefficient. Moreover, the silk ionomer shells undergo remarkable softening with a drop in Young's modulus by more than an order of magnitude due to the swelling, stretching, and increase in material porosity. The ability to control permeability and mechanical properties in a wide range for the silk-based microcapsules, with distinguishing stability under harsh environmental conditions, provides an important system for controlled loading and release and applications in bioengineering. |
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Authors:
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Chunhong Ye; Irina Drachuk; Rossella Calabrese; Hongqi Dai; David L Kaplan; Vladimir V Tsukruk |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-26 |
Journal Detail:
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Title: Langmuir : the ACS journal of surfaces and colloids Volume: - ISSN: 1520-5827 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9882736 Medline TA: Langmuir Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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