Document Detail


Permanent wall stretching in porcine coronary and internal mammary arteries.
MedLine Citation:
PMID:  12963204     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Anastomotic connectors may induce substantial arterial wall deformation and, hence, wall injury. We studied arterial wall damage and repair after sustained large longitudinal elongation in the porcine coronary and internal mammary arteries in vivo. METHODS: A stretch device that elongates a part of the artery by 80% was implanted in 8 pigs. Elongated coronary arteries (n = 14) and internal mammary arteries (n = 15) were examined histologically at either 2 days (4 pigs) or 5 weeks of follow-up (4 pigs). RESULTS: No mural thrombus was observed at the elongated site. In the coronary artery at 2 days, few and only minor histologic changes were found. At 5 weeks, in two of seven coronary segments, a thin rim of intimal hyperplasia was found, in one case with a maximum thickness of 76 micro m. The internal mammary artery hardly showed any changes. CONCLUSIONS: Permanent longitudinal elongation by 80% caused little structural changes in the porcine coronary and internal mammary artery wall. Anastomotic connectors that impose relatively large deformations can be safely evaluated in the pig.
Authors:
Carolien J van Andel; Peter V Pistecky; Paul F Gründeman; Marc P Buijsrogge; Cornelius Borst
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  76     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-09     Completed Date:  2003-11-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  805-9; discussion 809-10     Citation Subset:  AIM; IM    
Affiliation:
Experimental Cardiology Laboratory, Heart Lung Center Utrecht, University Medical Center Utrecht, Utrecht, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Animals
Coronary Vessels / physiology*
Elasticity
Mammary Arteries / physiology*
Swine
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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