| Permanent and transient congenital hypothyroidism in Isfahan-Iran. | |
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MedLine Citation:
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PMID: 19349525 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To determine the prevalence of permanent and transient congenital hypothyroidism (CH) in Isfahan, Iran. METHODS: In 256 primarily diagnosed CH patients identified through the neonatal screening programme from May 2002 to February 2005, treatment was discontinued for 4 weeks and T4 and thyroid stimulating hormone (TSH) were measured. Permanent or transient CH was determined from the results of the thyroid function tests and the radiologic findings. Patients with TSH levels >6 (mIU/l) were diagnosed with permanent CH. RESULTS: Results were available from 204 patients, of whom 122 patients were diagnosed with permanent CH (59.8%) (prevalence 1:748 births), and 82 with transient hypothyroidism (prevalence 1:1114). Permanent CH was associated with higher initial TSH levels than transient hypothyroidism (P < 0.05). The most common aetiology of CH was dyshormonogenesis. CONCLUSION: The rates of both permanent and transient CH in our study were higher than the comparable worldwide rates. The transient group had low T4 levels, suggesting that iodine contamination should be investigated. The aetiology of CH was also different from that recorded in many other studies. |
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Authors:
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Mahin Hashemipour; Silva Hovsepian; Roya Kelishadi; Ramin Iranpour; Rezvane Hadian; Sassan Haghighi; Angineh Gharapetian; Mojtaba Talaei; Massoud Amini |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of medical screening Volume: 16 ISSN: 0969-1413 ISO Abbreviation: J Med Screen Publication Date: 2009 |
Date Detail:
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Created Date: 2009-04-07 Completed Date: 2009-06-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9433359 Medline TA: J Med Screen Country: England |
Other Details:
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Languages: eng Pagination: 11-6 Citation Subset: IM |
Affiliation:
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Endocrinology, Endocrine & Metabolism Research Center, Isfahan University of Medical Sciences, Sedigheh Tahereh Medical Research Complex, Khorram Street, Jomhouri Square, Isfahan 8187698191, Iran. hashemipour@med.mui.ac.ir |
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| MeSH Terms | |
Descriptor/Qualifier:
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Congenital Hypothyroidism
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diagnosis*,
epidemiology*,
etiology Female Humans Hypothyroidism / diagnosis, epidemiology*, etiology Infant, Newborn Iran / epidemiology Male Neonatal Screening Thyroid Function Tests |
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