Document Detail


Permanent and transient congenital hypothyroidism in Isfahan-Iran.
MedLine Citation:
PMID:  19349525     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To determine the prevalence of permanent and transient congenital hypothyroidism (CH) in Isfahan, Iran. METHODS: In 256 primarily diagnosed CH patients identified through the neonatal screening programme from May 2002 to February 2005, treatment was discontinued for 4 weeks and T4 and thyroid stimulating hormone (TSH) were measured. Permanent or transient CH was determined from the results of the thyroid function tests and the radiologic findings. Patients with TSH levels >6 (mIU/l) were diagnosed with permanent CH. RESULTS: Results were available from 204 patients, of whom 122 patients were diagnosed with permanent CH (59.8%) (prevalence 1:748 births), and 82 with transient hypothyroidism (prevalence 1:1114). Permanent CH was associated with higher initial TSH levels than transient hypothyroidism (P < 0.05). The most common aetiology of CH was dyshormonogenesis. CONCLUSION: The rates of both permanent and transient CH in our study were higher than the comparable worldwide rates. The transient group had low T4 levels, suggesting that iodine contamination should be investigated. The aetiology of CH was also different from that recorded in many other studies.
Authors:
Mahin Hashemipour; Silva Hovsepian; Roya Kelishadi; Ramin Iranpour; Rezvane Hadian; Sassan Haghighi; Angineh Gharapetian; Mojtaba Talaei; Massoud Amini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medical screening     Volume:  16     ISSN:  0969-1413     ISO Abbreviation:  J Med Screen     Publication Date:  2009  
Date Detail:
Created Date:  2009-04-07     Completed Date:  2009-06-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433359     Medline TA:  J Med Screen     Country:  England    
Other Details:
Languages:  eng     Pagination:  11-6     Citation Subset:  IM    
Affiliation:
Endocrinology, Endocrine & Metabolism Research Center, Isfahan University of Medical Sciences, Sedigheh Tahereh Medical Research Complex, Khorram Street, Jomhouri Square, Isfahan 8187698191, Iran. hashemipour@med.mui.ac.ir
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MeSH Terms
Descriptor/Qualifier:
Congenital Hypothyroidism / diagnosis*,  epidemiology*,  etiology
Female
Humans
Hypothyroidism / diagnosis,  epidemiology*,  etiology
Infant, Newborn
Iran / epidemiology
Male
Neonatal Screening
Thyroid Function Tests

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