Document Detail

Permanent alterations in stress responsivity in female offspring subjected to combined maternal lead exposure and/or stress.
MedLine Citation:
PMID:  16140384     Owner:  NLM     Status:  MEDLINE    
Elevated lead (Pb) exposures preferentially impact low socioeconomic status (SES) populations, the same groups thought to sustain the highest levels of environmental stress. As co-occurring risk factors, therefore, Pb and stress could interact, a possibility further supported by the fact that both act on mesocorticolimbic dopamine systems of the brain. We recently demonstrated in rats that maternal Pb exposure could permanently increase basal corticosterone levels of offspring consistent with altered hypothalamic pituitary adrenal (HPA) axis function. The current study was thus designed to test the hypothesis that stress responsivity of offspring should likewise be altered, with the outcome differing in response to Pb, stress or Pb+stress. The impact of intermittent variable stress challenges (restraint, novelty, cold) on behavior sensitive to Pb exposure (fixed interval (FI) schedule-controlled responding) and on stress-induced corticosterone changes were evaluated in adult female offspring of dams that had been exposed to Pb (150 ppm) in drinking water from 2 months prior to breeding through lactation with or without maternal restraint stress on days 16 and 17 of gestation. This design yielded four treatment groups: (NS/0, no maternal Pb, no maternal stress; S/0, no maternal Pb, maternal stress; NS/150, maternal Pb, no maternal stress; and S/150, maternal Pb exposure and maternal stress). While maternal Pb alone and stress alone each altered components of stress responsivity, the greatest number of effects was seen in response to Pb + stress. This included alterations in FI performance following both restraint and cold stress and in the corticosterone response to cold stress. Collectively, these studies reveal that maternal Pb exposure alone can permanently alter stress responsivity and that the profile of effects produced by maternal Pb differ from those produced by maternal Pb in conjunction with stress, findings which have both mechanistic and risk assessment significance.
M B Virgolini; M R Bauter; D D Weston; D A Cory-Slechta
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2005-09-02
Journal Detail:
Title:  Neurotoxicology     Volume:  27     ISSN:  0161-813X     ISO Abbreviation:  Neurotoxicology     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-06     Completed Date:  2007-01-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7905589     Medline TA:  Neurotoxicology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  11-21     Citation Subset:  IM    
Environmental and Occupational Health Sciences Institute, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA.
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MeSH Terms
Animals, Newborn
Conditioning, Operant
Corticosterone / blood
Environmental Pollutants / toxicity*
Hypothalamo-Hypophyseal System / drug effects
Lead / blood,  toxicity*
Maternal Exposure
Maternal-Fetal Exchange
Prenatal Exposure Delayed Effects*
Sex Factors
Stress, Physiological / blood,  etiology,  physiopathology*
Grant Support
Reg. No./Substance:
0/Environmental Pollutants; 50-22-6/Corticosterone; 7439-92-1/Lead

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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