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Permanent and Transient Congenital Hypothyroidism in preterm infants.
MedLine Citation:
PMID:  22107264     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aim:  Transient fluctuations in thyroid function are well recognized in preterm infants. We wanted to assess TSH variation in babies with transient and permanent congenital hypothyroidism (CHT). Methods:  Whole bloodspot TSH data in preterm infants (<35 weeks; 2005-2010) were assessed and infants with bloodspot TSH values >6mU/l identified. Permanent CHT was defined as a requirement for thyroxine beyond 3 years of age. Results:  A first TSH sample was obtained from 5518 infants (median gestational age 32w, range 22-35), with a second sample obtained from 5134 (32w, 23-35). Five infants had raised TSH concentrations on both occasions. Three of the five infants had a serum TSH >80mU/l on second screen but came off thyroxine beyond 3 years of age. All preterm babies with permanent or transient hypothyroidism were detected by the first TSH cut-off of 6mU/l. Only one infant with a birth weight less than 1500g remains on thyroxine treatment beyond 2 years of age. Conclusions:  The incidence of permanent CHT in preterm infants is similar to term infants. Profound abnormalities of thyroid function can occur in preterm babies with transient hypothyroidism but both categories of hypothyroidism can be detected by a 'once-only' TSH screening strategy with a relatively low cut-off.
Authors:
R Srinivasan; S Harigopal; S Turner; T Cheetham
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-22
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  -     ISSN:  1651-2227     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Acta Paediatrica © 2011 Foundation Acta Paediatrica.
Affiliation:
Department Of Paediatric Endocrinology, The Great North Children's Hospital, Newcastle Upon Tyne, NE14LP, UK. Neonatal Intensive Care Unit, The Great North Children's Hospital, Newcastle Upon Tyne, NE1 4LP, UK. Department of Clinical Biochemistry, The Great North Children's Hospital, Newcastle Upon Tyne, NE1 4LP, UK.
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