Document Detail

Perlecan signaling: helping hedgehog stimulate prostate cancer growth.
MedLine Citation:
PMID:  16750652     Owner:  NLM     Status:  MEDLINE    
Perlecan, an extracellular matrix proteoglycan, regulates signaling by a variety of growth factors through protein-protein and protein-carbohydrate interactions. Recent evidence demonstrates that Perlecan modulates sonic hedgehog signaling during both development and neoplasia, in particular in prostate cancer. Perlecan directly binds to sonic hedgehog and is required for its signaling. Increased sonic hedgehog signaling due to Perlecan in aggressive and metastatic prostate cancer cells can be attributed to increased Perlecan expression or changes in Perlecan glycan structure. Additional co-localization studies suggest that other tumor types may also have a Perlecan-modulated hedgehog signaling pathway. Inhibitors of Perlecan function at either the protein or glycan level would be ideal drug candidates for anti-cancer therapies.
Sumana Datta; Michael Pierce; Milton W Datta
Publication Detail:
Type:  Journal Article; Review     Date:  2006-04-25
Journal Detail:
Title:  The international journal of biochemistry & cell biology     Volume:  38     ISSN:  1357-2725     ISO Abbreviation:  Int. J. Biochem. Cell Biol.     Publication Date:  2006  
Date Detail:
Created Date:  2006-07-25     Completed Date:  2006-09-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9508482     Medline TA:  Int J Biochem Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1855-61     Citation Subset:  IM    
Department of Biochemistry and Biophysics, MS 2128, Texas A&M University, College Station, TX 77843-2128, United States.
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MeSH Terms
Hedgehog Proteins
Heparan Sulfate Proteoglycans / chemistry,  metabolism,  physiology*
Models, Biological
Molecular Structure
Prostatic Neoplasms / metabolism*,  pathology,  physiopathology
Signal Transduction / physiology*
Trans-Activators / metabolism*,  physiology
Reg. No./Substance:
0/Hedgehog Proteins; 0/Heparan Sulfate Proteoglycans; 0/SHH protein, human; 0/Trans-Activators; 143972-95-6/perlecan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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