Document Detail


Periventricular white matter hyperintensities on MRI: correlation with neuropathologic findings.
MedLine Citation:
PMID:  10666976     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Periventricular white matter hyperintensities on postmortem magnetic resonance imaging (MRI) and myelin-stained frontal and parietal histologic sections were evaluated independently in 12 cases. There was a strong relationship between the extent of white matter hyperintensities on MRI and the extent of gross and microscopic changes seen in the white matter of myelin-stained sections, particularly in the frontal lobe. In this material, the extent of myelin rarefaction correlated with a 0- to 8-point white matter hyperintensity scale rating on MRI in the same brains.
Authors:
C D Smith; D Snowdon; W R Markesbery
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neuroimaging : official journal of the American Society of Neuroimaging     Volume:  10     ISSN:  1051-2284     ISO Abbreviation:  J Neuroimaging     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-03-02     Completed Date:  2000-03-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9102705     Medline TA:  J Neuroimaging     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  13-6     Citation Subset:  IM    
Affiliation:
Sanders-Brown Center on Aging, University of Kentucky Medical Center, Lexington 40536, USA.
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MeSH Terms
Descriptor/Qualifier:
Aging / pathology
Brain / pathology*
Cadaver
Female
Humans
Magnetic Resonance Imaging*
Statistics, Nonparametric
Grant Support
ID/Acronym/Agency:
5P50AG05144/AG/NIA NIH HHS; K04AG00553/AG/NIA NIH HHS; R01AG09862/AG/NIA NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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