Document Detail


Periventricular preoptic area neurons coactivated with luteinizing hormone (LH)-releasing hormone (LHRH) neurons at the time of the LH surge are LHRH afferents.
MedLine Citation:
PMID:  9886864     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Earlier studies demonstrated coactivation of the periventricular preoptic area (pePOA) with LHRH neurons at the time of an induced or spontaneous LH surge, suggesting that the pePOA might regulate LHRH neurons. To investigate this hypothesis, studies were conducted to determine the temporal pattern of pePOA Fos activation during the rat estrous cycle and establish the connections of the pePOA neurons with LHRH neurons. Fos activation within LHRH and pePOA neurons showed the same temporal pattern. Both were absent during diestrous I, diestrous II, and the morning of proestrus. Fos was induced in the pePOA and LHRH neurons beginning on the afternoon of proestrus (4 h before lights off), with a decline 8 h later on proestrous evening. Tract-tracing studies then established the relationship between LHRH and pePOA neurons. Retrograde labeling with fluorogold determined that a portion of the Fos-positive pePOA neurons present at the time of the LH surge sent a projection to regions that contain LHRH cells. Anterograde tracer (neurobiotin) injections established that the pePOA neurons sent axons to the LHRH cells. Taken together, these data indicate that the pePOA provides direct input to LHRH neurons that is likely to stimulate LHRH neurons at the time of the LH surge.
Authors:
W W Le; K A Berghorn; S Rassnick; G E Hoffman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Endocrinology     Volume:  140     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-01-28     Completed Date:  1999-01-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  510-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore 21201, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Diestrus
Female
Gonadotropin-Releasing Hormone / physiology*
Immunohistochemistry
Luteinizing Hormone / blood*
Neurons, Afferent / physiology*
Preoptic Area / cytology*
Proestrus
Proto-Oncogene Proteins c-fos / metabolism
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
NS-28730/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos; 33515-09-2/Gonadotropin-Releasing Hormone; 9002-67-9/Luteinizing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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