Document Detail

Periventricular nodular heterotopia: prenatal ultrasound and magnetic resonance findings.
MedLine Citation:
PMID:  23151899     Owner:  NLM     Status:  Publisher    
Objectives: to describe in ultrasonography (US) and magnetic resonance imaging (MRI) the prenatal findings suggestive of periventricular nodular heterotopia (PNH). Methods: this retrospective case series included fetuses referred for MRI and diagnosed with PNH, which were confirmed by post-natal MRI or autopsy. The type of PNH, associated ventriculomegaly and associated malformations were reported. Results: 11 fetuses were included (9 females, 2 males) with a mean gestational age at diagnosis of 31 weeks' gestation (23-34). PNH were small and diffuse (n = 7), large and multiple (n = 1) or single (n = 3). A targeted US scan performed before fetal MRI missed the diagnosis in 4 cases [diffuse (n = 1) and single (n = 3)]. Another US scan performed after MRI diagnosed PNH in 2 of these 4 cases. Ventriculomegaly was present in 6 cases [uni-(n = 4) or bilateral (n = 2)]. All PNH appeared as nodules of intermediate echogenicity protruding into the ventricular lumen. In all cases of diffuse PNH, the frontal horns and bodies of the lateral ventricles displayed a square shape with irregular borders. Associated cerebral malformations were observed in 7 cases and included corpus callosum agenesis (n = 4 with additional malformations in 2 cases) and retrocerebellar cyst (n = 3). Extracerebral malformations were also present (n = 2). Maternal MRI was performed in 5/6 cases of isolated small and diffuse PNH in female fetuses and demonstrated PNH in 2 cases. Conclusion: PNH are underdiagnosed at prenatal US even on targeted scans. Indented ventricular borders on axial views and irregular square shaped lateral ventricles on coronal views are suggestive of PNH at prenatal US. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Eléonore Blondiaux; Chiara Sileo; Catherine Nahama-Allouche; Marie-Laure Moutard; Antoinette Gelot; Jean-Marie Jouannic; Hubert Ducou le Pointe; Catherine Garel
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-14
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  -     ISSN:  1469-0705     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Service de Radiologie, Hôpital Trousseau - Hôpitaux Universitaires de l'Est Parisien (APHP).
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