|Periventricular leukomalacia with late-onset circulatory dysfunction of premature infants: correlation with severity of magnetic resonance imaging findings and neurological outcomes.|
|PMID: 17146199 Owner: NLM Status: MEDLINE|
|The incidence of late-onset circulatory dysfunction (LCD) of premature infants, which is characterized by sudden hypotension and oliguria, has recently increased in Japan. This condition suddenly occurs after several days of age without obvious causes in preterm infants with stable respiration and circulation. Intravenous steroids frequently improve the hypotension. The main problem with LCD is the subsequent and frequent onset of periventricular leukomalacia (PVL), and neurological development appears to be worse in PVL patients with LCD than those without LCD. The aim of this study was to determine whether the severity of magnetic resonance imaging (MRI) findings and neurological outcomes differ between infants who developed PVL after LCD and those who developed PVL without LCD. We retrospectively studied preterm infants who were delivered at less than 33 weeks of gestation between the years 2000 and 2003. During the study period, 10 and 26 infants developed PVL with and without LCD, respectively. The incidence of severe or moderate MRI findings was significantly higher in PVL patients with LCD (100%) than those without LCD (50%; p < 0.05). The incidence of severe cerebral palsy was 88% in PVL infants with LCD and 43% in PVL infants without LCD (p < 0.05). Moreover, the incidence of visual disorders was significantly higher in PVL infants with LCD (63%) than those without LCD (9%; p < 0.01). In conclusion, neurological outcomes are worse in preterm infants who develop PVL with LCD than those without LCD, which is well correlated to the severity judged by MRI findings.|
|Satoru Kobayashi; Shinji Fujimoto; Sumio Fukuda; Ayako Hattori; Toshimitsu Iwaki; Norihisa Koyama; Taihei Tanaka; Minoru Kokubo; Tohru Okanishi; Hajime Togari|
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|Type: Journal Article; Multicenter Study|
|Title: The Tohoku journal of experimental medicine Volume: 210 ISSN: 0040-8727 ISO Abbreviation: Tohoku J. Exp. Med. Publication Date: 2006 Dec|
|Created Date: 2006-12-05 Completed Date: 2007-01-09 Revised Date: -|
Medline Journal Info:
|Nlm Unique ID: 0417355 Medline TA: Tohoku J Exp Med Country: Japan|
|Languages: eng Pagination: 333-9 Citation Subset: IM|
|Department of Pediatrics, Neonatology and Congenital Disorders, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. firstname.lastname@example.org|
|APA/MLA Format Download EndNote Download BibTex|
Cerebral Palsy / etiology*
Epilepsy / etiology
Hearing Loss / etiology
Hypotension / complications
Hypoxia-Ischemia, Brain / complications*
Infant, Low Birth Weight
Infant, Premature / physiology*
Leukomalacia, Periventricular / complications*, pathology, ultrasonography
Magnetic Resonance Imaging*
Oliguria / complications
Severity of Illness Index
Vascular Diseases / complications
Vision Disorders / etiology
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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