Document Detail

Periventricular leukomalacia with late-onset circulatory dysfunction of premature infants: correlation with severity of magnetic resonance imaging findings and neurological outcomes.
MedLine Citation:
PMID:  17146199     Owner:  NLM     Status:  MEDLINE    
The incidence of late-onset circulatory dysfunction (LCD) of premature infants, which is characterized by sudden hypotension and oliguria, has recently increased in Japan. This condition suddenly occurs after several days of age without obvious causes in preterm infants with stable respiration and circulation. Intravenous steroids frequently improve the hypotension. The main problem with LCD is the subsequent and frequent onset of periventricular leukomalacia (PVL), and neurological development appears to be worse in PVL patients with LCD than those without LCD. The aim of this study was to determine whether the severity of magnetic resonance imaging (MRI) findings and neurological outcomes differ between infants who developed PVL after LCD and those who developed PVL without LCD. We retrospectively studied preterm infants who were delivered at less than 33 weeks of gestation between the years 2000 and 2003. During the study period, 10 and 26 infants developed PVL with and without LCD, respectively. The incidence of severe or moderate MRI findings was significantly higher in PVL patients with LCD (100%) than those without LCD (50%; p < 0.05). The incidence of severe cerebral palsy was 88% in PVL infants with LCD and 43% in PVL infants without LCD (p < 0.05). Moreover, the incidence of visual disorders was significantly higher in PVL infants with LCD (63%) than those without LCD (9%; p < 0.01). In conclusion, neurological outcomes are worse in preterm infants who develop PVL with LCD than those without LCD, which is well correlated to the severity judged by MRI findings.
Satoru Kobayashi; Shinji Fujimoto; Sumio Fukuda; Ayako Hattori; Toshimitsu Iwaki; Norihisa Koyama; Taihei Tanaka; Minoru Kokubo; Tohru Okanishi; Hajime Togari
Related Documents :
18544009 - Cerebral palsy in term infants: a clinicopathologic analysis of 158 medicolegal case re...
17146199 - Periventricular leukomalacia with late-onset circulatory dysfunction of premature infan...
2755549 - Cerebral palsy in tottori, japan. benefits and risks of progress in perinatal medicine.
9131309 - Antenatal and delivery risk factors simultaneously associated with neonatal death and c...
23736989 - Interconception care for women with a history of gestational diabetes for improving mat...
17854979 - In vitro evaluation of dual mode ultrasonic thrombolysis method for transcranial applic...
1738219 - Concurrent administration of albumin with total parenteral nutrition in sick newborn in...
24072739 - Hypothyroidism and iodine deficiency in an infant requiring total parenteral nutrition.
8854459 - The health effects of earthquakes in the mid-1990s.
Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  210     ISSN:  0040-8727     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-05     Completed Date:  2007-01-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  333-9     Citation Subset:  IM    
Department of Pediatrics, Neonatology and Congenital Disorders, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Circulation / physiology*
Cerebral Palsy / etiology*
Disease Progression
Epilepsy / etiology
Gestational Age
Hearing Loss / etiology
Hypotension / complications
Hypoxia-Ischemia, Brain / complications*
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature / physiology*
Leukomalacia, Periventricular / complications*,  pathology,  ultrasonography
Magnetic Resonance Imaging*
Oliguria / complications
Retrospective Studies
Severity of Illness Index
Time Factors
Vascular Diseases / complications
Vision Disorders / etiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Nurses' professed knowledge of genetics and genetic counseling.
Next Document:  Accelerated decrease in bone mineral density in women aged 52-57 years.