Document Detail

Periventricular leukomalacia and retinopathy in a term infant born to a mother with asthma.
MedLine Citation:
PMID:  16542519     Owner:  NLM     Status:  MEDLINE    
A male child, born at 37+5 gestational weeks (GWs) (birthweight 2000g) after intrauterine growth retardation (IUG; -3 SD), to a mother treated during pregnancy for asthma, developed periventricular leukomalacia and retinopathy with total retinal detachment in the left eye and partial detachment in the right eye. Apart from basic asthma treatment with terbutalin, budesonid, and fenoterolhydrobromid throughout the pregnancy, she was treated with intravenous or oral cortisone for 6.5 weeks from 28+5 GWs. In addition she developed deep venous thrombosis at 29 GWs and was treated with heparin until delivery. Psychotic symptoms during the 31st GW were treated with diazepam, haloperidol, and levomepromazin. Functional sequelae for the child were visual impairment (visual acuity 5/60), uneven intellectual profile (Wechsler Pre-school and Primary Scale of Intelligence, Verbal IQ 94 and Performance IQ 32 at 8y of age), and autistic-like behaviour. The possibility that pre- and perinatal risk factors (e.g. severe maternal illness, IUGR, and cortisone treatment) in a term infant may create conditions for developing eye and brain pathologies commonly closely related to preterm birth should be considered.
Nina Hagwall; Eva Engström; Ann Hellström; Lena Jacobson
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Developmental medicine and child neurology     Volume:  48     ISSN:  0012-1622     ISO Abbreviation:  Dev Med Child Neurol     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-17     Completed Date:  2006-05-02     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0006761     Medline TA:  Dev Med Child Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  301-3     Citation Subset:  IM    
Department of Ophthalmology, Ryhov Hospital, Jönköping, Sweden.
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MeSH Terms
Anti-Asthmatic Agents / therapeutic use
Anti-Inflammatory Agents / therapeutic use
Anticoagulants / therapeutic use
Asthma / drug therapy
Fetal Growth Retardation
Infant, Newborn
Leukomalacia, Periventricular / etiology*
Pregnancy Complications / drug therapy*
Retinal Detachment / etiology*
Retinal Dysplasia / etiology*
Tranquilizing Agents / therapeutic use
Reg. No./Substance:
0/Anti-Asthmatic Agents; 0/Anti-Inflammatory Agents; 0/Anticoagulants; 0/Tranquilizing Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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