Document Detail

Periventricular leucomalacia and neurodevelopmental outcome in preterm infants.
MedLine Citation:
PMID:  2434037     Owner:  NLM     Status:  MEDLINE    
During an 18 month period, 120 preterm infants of 34 weeks' gestation or less were prospectively examined for periventricular leucomalacia (PVL) by cerebral ultrasound. Neurological and developmental assessment was carried out at 18 months of age corrected for prematurity in 82 surviving neonates. The developmental outcome (Griffiths development quotient) was above 80 and similar in infants with normal scans (n = 41), isolated periventricular-intraventricular haemorrhage (n = 13), and post-haemorrhagic hydrocephalus (n = 4), and no major handicap was diagnosed in these groups. By contrast, the prognosis was variable and poorer in infants with PVL (n = 24) and depended on the extent and site of the lesion. Infants with frontal PVL (n = 13) developed normally. Major sequelae (n = 8) were closely related to frontal-parietal PVL and frontal-parietal-occipital PVL and could be ascribed to the presence of cysts as well as to a persistent hyperechogenic ultrasonographic PVL appearance. A relation between size and site of the lesion and type and severity of the handicap was established.
C L Fawer; P Diebold; A Calame
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of disease in childhood     Volume:  62     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-03-26     Completed Date:  1987-03-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  30-6     Citation Subset:  AIM; IM    
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MeSH Terms
Developmental Disabilities / etiology*
Encephalomalacia / complications*
Infant, Newborn
Infant, Premature, Diseases / complications*
Leukomalacia, Periventricular / complications*,  diagnosis
Nervous System / physiopathology
Nervous System Diseases / etiology*
Prospective Studies

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