| Periventricular hemorrhagic infarction: risk factors and neonatal outcome. | |
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MedLine Citation:
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PMID: 16876002 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to define the incidence, clinical associations, and short-term outcome of periventricular hemorrhagic infarction in the modern neonatal intensive care unit. From 5774 infants (birth weight<2500 gm), periventricular hemorrhagic infarction diagnosed by cranial ultrasound was identified and confirmed. gestational age-matched control infants were identified with normal cranial ultrasounds and detailed clinical data were obtained in both groups. Periventricular hemorrhagic infarction was confirmed in 58 infants. Incidence was 0.1% (1500-2500 gm), 2.2% (750-1500 gm), and 10% (<750 gm). Data across 6 study years reveal increased incidence in infants<750 gm. Compared with control infants, infants with periventricular hemorrhagic infarction had significantly greater association with assisted conception, intrapartum factors (emergency cesarean section, low Apgar scores), early neonatal complications (patent ductus arteriosus, pneumothorax, pulmonary hemorrhage), blood gas disturbances, and need for pressor, volume infusion, and respiratory support. Neonatal mortality of this group was 40% (n=23). Survivors had longer duration of mechanical ventilation and critical care stay compared with control subjects. Thirty-seven percent of survivors required cerebrospinal fluid shunt placement. Periventricular hemorrhagic infarction remains an important neurologic complication of prematurity. A growing population of survivors is apparent among infants with birth weight<750 gm. Multiple hemodynamic factors associated with periventricular hemorrhagic infarction cluster in the intrapartum and early neonatal periods. |
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Authors:
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Haim Bassan; Henry A Feldman; Catherine Limperopoulos; Carol B Benson; Steven A Ringer; Elaine Veracruz; Janet S Soul; Joseph J Volpe; Adré J du Plessis |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatric neurology Volume: 35 ISSN: 0887-8994 ISO Abbreviation: Pediatr. Neurol. Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-07-31 Completed Date: 2006-10-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8508183 Medline TA: Pediatr Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 85-92 Citation Subset: IM |
Affiliation:
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Department of Neurology, Neonatal Neurology Research Group, Children's Hospital Boston and Harvard Medical School, Boston Massachusetts 02115, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cerebral Hemorrhage
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epidemiology*,
mortality,
therapy Cerebral Infarction / epidemiology*, mortality, therapy Cerebral Ventricles* Female Humans Incidence Infant, Low Birth Weight Infant, Newborn Infant, Premature Infant, Premature, Diseases / epidemiology*, therapy Intensive Care, Neonatal* Outcome Assessment (Health Care) Pregnancy Retrospective Studies Risk Factors Survival Rate |
| Grant Support | |
ID/Acronym/Agency:
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M01-RR02172/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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