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Periventricular hemorrhage: A problem still today.
MedLine Citation:
PMID:  23058297     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Periventricular hemorrhage (PVH) is the result of "temporary" fragile blood vessels and unstable circulation in the brain of very premature infants. Antenatal corticosteroids have substantially reduced PVH. Avoidance of intrapartum hypoxia and birth trauma has probably helped as has better cardio-respiratory stabilization after delivery. Increased survival of the highest risk infants under 26weeks gestation means that there are probably 800-900 infants with severe PVH annually in the UK. Delayed cord clamping could probably reduce PVH further. Various medications can reduce PVH but have not been widely adopted as the imaging has not translated into reduced disability. Posthemorrhagic ventricular dilatation (PHVD) and parenchymal hemorrhagic infarction both greatly increase disability. Treatment of PHVD is based on avoiding pressure and gross distortion of the vulnerable white matter. Further research needs to investigate whether treating subtle seizures, removing blood or blocking free radicals or inflammation will improve prognosis.
Authors:
Andrew Whitelaw
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-8
Journal Detail:
Title:  Early human development     Volume:  -     ISSN:  1872-6232     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Emeritus Professor of Neonatal Medicine, University of Bristol, Bristol, United Kingdom. Electronic address: andrew.whitelaw@bristol.ac.uk.
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