Document Detail

Periventricular haemorrhage in very low birth weight Malaysian neonates.
MedLine Citation:
PMID:  8411316     Owner:  NLM     Status:  MEDLINE    
A prospective study was carried out to determine the incidence, clinical presentation, early outcome, and risk factors associated with periventricular haemorrhage (PVH) in 88 (84 per cent) of the 105 consecutive very low birth weight (VLBW) (< 1500 g) Malaysian neonates born in the Maternity Hospital, Kuala Lumpur. Based on the cranial ultrasound findings, PVH was detected in 86 of the 88 neonates (98 per cent, 95 per cent confidence intervals: 95 to 101). Seventeen (20 per cent) of them had grade I, 52 (61 per cent) had grade II, 7 (8 per cent) had grade III and 10 (12 per cent) had grade IV PVH. PVH was detected in all the affected neonates by the fifth day of life. Sixty-four neonates (74 per cent) were symptomatic when PVH was first detected. Shock (P < 0.01), pallor (P = 0.028), low haematocrit of less than 40 per cent (P < 0.01), convulsion (P < 0.001), and bulging of anterior fontanelle (P = 0.019) were significantly more common in the neonates with severe PVH (grades III or IV). Death occurred in 43/86 (50 per cent, 95 per cent confidence interval: 39-61 per cent) of the neonates with PVH before their first discharge from the hospital. Ventriculomegaly developed in 29/43 (67 per cent, 95 per cent confidence intervals: 54.4-81.4) of the survivors with PVH. Our study suggests that PVH is a common problem in the Malaysian VLBW neonates. To reduce the incidence and severity of this condition, prevention of preterm delivery and improvement in the basic facilities for neonatal care would help.
N Y Boo; L C Ong; M S Lye; K P Wong; M Mastura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of tropical pediatrics     Volume:  39     ISSN:  0142-6338     ISO Abbreviation:  J. Trop. Pediatr.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-11-23     Completed Date:  1993-11-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8010948     Medline TA:  J Trop Pediatr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  224-9     Citation Subset:  IM    
Department of Paediatrics, Faculty of Medicine, National University of Malaysia, Jalan Raja Muda, Kuala Lumpur.
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MeSH Terms
Age of Onset
Brain Diseases / diagnosis,  physiopathology
Cerebral Ventricles / physiopathology*,  ultrasonography
Health Promotion
Hemorrhage / diagnosis*,  epidemiology,  physiopathology
Infant, Low Birth Weight*
Infant, Newborn
Malaysia / epidemiology
Prospective Studies
Risk Factors
Severity of Illness Index

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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