Document Detail

Perivenous application of fibrin glue prevents the early injury of jugular vein graft to arterial circulation in rabbits.
MedLine Citation:
PMID:  16537025     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Placement of an external support has been reported to prevent intimal hyperplasia of vein grafts. However, it is limited by potential complications. In the present study, we investigated the effect of fibrin glue on preventing vein graft failure as perivenous application. METHODS: Twenty-four rabbits were divided into non-supported group (n = 12) and fibrin glue group (n = 12). All animals underwent unilateral jugular vein into common carotid artery interposition grafting and then fibrin glue was applied as perivenous support. Samples of tissues were harvested after 4 weeks. RESULTS: The vein grafts with fibrin glue demonstrated a statistically significant decrease in proliferating cell nuclear antigen in the medial/intimal region [13.38% (11.26% - 15.11%)] compared with non-supported vein grafts [31.22% (27.15% - 35.98%)] (P < 0.001). Light microscopy showed remarkable attenuation of endothelial cell loss and numerous microvessels in neoadventitia in the fibrin glue group compared with the non-supported group. The smooth muscle cells migrated into adventitia significantly in fibrin glue group, whereas the smooth muscle cells migrated into intima in non-supported group. Conclusion Perivenous support of vein graft with fibrin glue in vivo can attenuate the severe injury encountered in the non-supported vein grafts exposed to artery.
Li Wan; Dian-yuan Li; Bing Yang; Qing-yu Wu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chinese medical journal     Volume:  119     ISSN:  0366-6999     ISO Abbreviation:  Chin. Med. J.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-03-15     Completed Date:  2006-03-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7513795     Medline TA:  Chin Med J (Engl)     Country:  China    
Other Details:
Languages:  eng     Pagination:  300-4     Citation Subset:  IM    
Department of Cardiovascular Surgery, Cardiovascular Institute, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China.
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MeSH Terms
Carotid Artery, Common / surgery*
Cell Movement
Coronary Artery Bypass
Fibrin Tissue Adhesive / pharmacology*
Jugular Veins / transplantation*
Muscle, Smooth, Vascular / pathology
Proliferating Cell Nuclear Antigen / analysis
Tunica Intima / pathology
Reg. No./Substance:
0/Fibrin Tissue Adhesive; 0/Proliferating Cell Nuclear Antigen

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