| Perivenous application of fibrin glue prevents the early injury of jugular vein graft to arterial circulation in rabbits. | |
| | |
MedLine Citation:
|
PMID: 16537025 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Placement of an external support has been reported to prevent intimal hyperplasia of vein grafts. However, it is limited by potential complications. In the present study, we investigated the effect of fibrin glue on preventing vein graft failure as perivenous application. METHODS: Twenty-four rabbits were divided into non-supported group (n = 12) and fibrin glue group (n = 12). All animals underwent unilateral jugular vein into common carotid artery interposition grafting and then fibrin glue was applied as perivenous support. Samples of tissues were harvested after 4 weeks. RESULTS: The vein grafts with fibrin glue demonstrated a statistically significant decrease in proliferating cell nuclear antigen in the medial/intimal region [13.38% (11.26% - 15.11%)] compared with non-supported vein grafts [31.22% (27.15% - 35.98%)] (P < 0.001). Light microscopy showed remarkable attenuation of endothelial cell loss and numerous microvessels in neoadventitia in the fibrin glue group compared with the non-supported group. The smooth muscle cells migrated into adventitia significantly in fibrin glue group, whereas the smooth muscle cells migrated into intima in non-supported group. Conclusion Perivenous support of vein graft with fibrin glue in vivo can attenuate the severe injury encountered in the non-supported vein grafts exposed to artery. |
| | |
Authors:
|
Li Wan; Dian-yuan Li; Bing Yang; Qing-yu Wu |
Related Documents
:
|
18209915 - Elective vs non-elective radial artery grafts: comparing midterm results through 64-sli... 11562595 - Popliteo-distal and tibio-tibial bypasses: a viable alternative for the revascularisati... 15599475 - Infrapopliteal-lower extremity revascularization with prosthetic conduit: a 20-year exp... 8203975 - Cryopreserved saphenous vein allografts for below-knee lower extremity revascularization. 3966135 - Hemodynamics of portal blood flow shown by ct portography. work in progress. 15875195 - Perfusion abnormalities in congenital and neoplastic pulmonary disease: comparison of m... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Chinese medical journal Volume: 119 ISSN: 0366-6999 ISO Abbreviation: Chin. Med. J. Publication Date: 2006 Feb |
Date Detail:
|
Created Date: 2006-03-15 Completed Date: 2006-03-30 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7513795 Medline TA: Chin Med J (Engl) Country: China |
Other Details:
|
Languages: eng Pagination: 300-4 Citation Subset: IM |
Affiliation:
|
Department of Cardiovascular Surgery, Cardiovascular Institute, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Carotid Artery, Common / surgery* Cell Movement Coronary Artery Bypass Fibrin Tissue Adhesive / pharmacology* Hyperplasia Jugular Veins / transplantation* Muscle, Smooth, Vascular / pathology Proliferating Cell Nuclear Antigen / analysis Rabbits Tunica Intima / pathology |
| Chemical | |
Reg. No./Substance:
|
0/Fibrin Tissue Adhesive; 0/Proliferating Cell Nuclear Antigen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Relationship between apolipoprotein E, D10S1225 polymorphisms and late-onset Alzheimer's disease.
Next Document: Three-dimensional finite element analysis of weakened roots restored with different cements in combi...