Document Detail

Perivascular fibrosis of muscular pulmonary arteries in chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  1446465     Owner:  NLM     Status:  MEDLINE    
We performed a morphometric analysis of peribronchiolar and perivascular fibrosis in lungs obtained at autopsy from six patients with chronic bronchitis, six with pulmonary emphysema, and four normal control subjects. The areas of fibrosis outside the smooth muscle layer of bronchioles and outside the external elastic lamina of muscular pulmonary arteries were measured and their thickness was then calculated by assuming a round airway or artery. Patients with chronic bronchitis had significantly thicker peribronchiolar fibrosis in bronchioles of 1 mm or less in diameter and also thicker perivascular fibrosis of the adjacent muscular pulmonary arteries than the other two groups. The extent of perivascular fibrosis was significantly correlated with peribronchiolar fibrosis only in the muscular pulmonary arteries adjacent to the bronchioles but not in those away from the bronchioles. These findings suggest direct extension of chronic inflammation from bronchioles to the adjacent muscular pulmonary arteries in chronic bronchitis but not in pulmonary emphysema. Such perivascular fibrosis might lead to sustained pulmonary hypertension.
Y Andoh; S Shimura; T Aikawa; H Sasaki; T Takishima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chest     Volume:  102     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1992-12-29     Completed Date:  1992-12-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1645-50     Citation Subset:  AIM; IM    
First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
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MeSH Terms
Bronchi / pathology
Bronchitis / microbiology,  pathology*
Cell Count
Chronic Disease
Leukocyte Count
Lung / blood supply*,  microbiology,  pathology
Lymphocytes / pathology
Middle Aged
Muscle, Smooth, Vascular / pathology
Pseudomonas Infections / pathology
Pseudomonas aeruginosa / isolation & purification
Pulmonary Emphysema / microbiology,  pathology*
Pulmonary Fibrosis / microbiology,  pathology*
Tunica Intima / pathology
Tunica Media / pathology
Comment In:
Chest. 1994 Mar;105(3):973-4   [PMID:  8131590 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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