Document Detail


Perivascular epithelioid cell tumor of the liver coexisting with a gastrointestinal stromal tumor.
MedLine Citation:
PMID:  18205275     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Approximately 10% of patients with gastrointestinal stromal tumors (GIST) develop other neoplasms, either synchronously or metachronously. In this report we describe coexistence of a gastrointestinal stromal tumor and a hepatic perivascular epithelioid cell tumor (PEComa) in a 51-year-old woman with no evidence of tuberous sclerosis. A subcapsular hepatic nodule (0.8 cm in diameter) was found during surgery for symptomatic gastric neoplasm (15 cm in diameter) arising from the lesser curvature. Both tumors revealed histomorphological and immunohistochemical features confirming a diagnosis of a small incidental hepatic PEComa and a high risky extramural gastric GIST, respectively. The patient remained disease-free 25 mo after surgery with no evidence of tumor recurrence or new neoplasms. To our knowledge, this is the first report of PEComa in a patient with GIST. Hepatic lesions detected synchronously or metachronously in patients with GISTs may represent histogenetically distinct lesions and should be sampled to confirm or exclude metastatic GISTs.
Authors:
Carlos Eduardo Paiva; Francisco Alves Moraes Neto; Abbas Agaimy; Maria Aparecida Custodio Domingues; Silvia Regina Rogatto
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  14     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-21     Completed Date:  2008-05-20     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  800-2     Citation Subset:  IM    
Affiliation:
Oncological and Hemato-oncological Center, Sao Paulo State University, Rua Antonio Nunes da Silva Sobrinho, 180-Jardim Paraiso II-Botucatu, Sao Paulo 18610-170, Brazil. cepaiva@fmb.unesp.br
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MeSH Terms
Descriptor/Qualifier:
Epithelioid Cells / pathology*
Female
Gastrointestinal Stromal Tumors / pathology*,  radiography
Humans
Liver Neoplasms / pathology*,  radiography
Middle Aged
Neoplasms, Second Primary / pathology*,  radiography
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