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Perivascular epithelioid cell tumor of the ileum presenting as diverticulitis.
MedLine Citation:
PMID:  22953133     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Perivascular epithelioid cell tumors (PEComas) are a group of rare mesenchymal neoplasms. Gastrointestinal PEComas are exceptionally rare, there being only a few case reports in the literature involving the colon and small intestine. Nearly all PEComas show immunoreactivity for both melanocytic (HMB45 and/or Melan-A) and smooth muscle (actin and/or desmin) markers. A 36-year-old male was admitted to the hospital with acut- abdomen. At laparatomy, a nodular mass protruding from the ileum which clinically simulated a diverticulitis was noticed. Gross examination of the specimen revealed a 2 × 1,5 × 1 cm secondarily ulcerated, solid, nodular, gray white tumor mass in the ileal wall. Histologically, tumor cells were composed of nests of round-polygonal epithelioid cells with abundant clear to slightly eosinophilic granular cytoplasm and round vesicular nuclei. The nests were separated by thin fibrovascular septa. Minimal necrosis and low mitotic activity were noticed in the tumor. Immunohistochemically, tumor cells were positive for SMA, HMB45, and Melan-A and negative for CD10, RCC, CD45, CD117, CD34, EMA, and Desmin. Diagnosis was PEComa of the ileum. We report the case of ileal PEComa to remind the unusual presentation (diverticulitis) of these tumors, besides rarity and diagnostic difficulties.
Authors:
Saime Unluoglu; Umit Bayol; Nilay Korkmaz; Bekir Ozenen; Fuat Ipekci; Emel Ebru Pala
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Publication Detail:
Type:  Journal Article     Date:  2012-04-29
Journal Detail:
Title:  Case reports in pathology     Volume:  2012     ISSN:  2090-679X     ISO Abbreviation:  Case Rep Pathol     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-06     Completed Date:  2012-09-06     Revised Date:  2013-04-15    
Medline Journal Info:
Nlm Unique ID:  101576609     Medline TA:  Case Rep Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  476941     Citation Subset:  -    
Affiliation:
Department of Pathology, Tepecik Research and Training Hospital, Izmir, Turkey.
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