Document Detail


Perivascular adipose tissue and coronary vascular disease.
MedLine Citation:
PMID:  24790142     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Coronary perivascular adipose tissue is a naturally occurring adipose tissue depot that normally surrounds the major coronary arteries on the surface of the heart. Although originally thought to promote vascular health and integrity, there is a growing body of evidence to support that coronary perivascular adipose tissue displays a distinct phenotype relative to other adipose depots and is capable of producing local factors with the potential to augment coronary vascular tone, inflammation, and the initiation and progression of coronary artery disease. The purpose of the present review is to outline previous findings about the cardiovascular effects of coronary perivascular adipose tissue and the potential mechanisms by which adipose-derived factors may influence coronary vascular function and the progression of atherogenesis.
Authors:
Meredith Kohr Owen; Jillian N Noblet; Daniel J Sassoon; Abass M Conteh; Adam G Goodwill; Johnathan D Tune
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2014-05-01
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  34     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-07-17     Completed Date:  2014-09-08     Revised Date:  2014-11-17    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1643-9     Citation Subset:  IM    
Copyright Information:
© 2014 American Heart Association, Inc.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism*,  physiopathology
Animals
Coronary Artery Disease / genetics,  metabolism*,  physiopathology
Coronary Vessels / metabolism*,  physiopathology
Gene Expression Regulation
Humans
Paracrine Communication
Phenotype
Signal Transduction
Grant Support
ID/Acronym/Agency:
HL092245/HL/NHLBI NIH HHS; HL117620/HL/NHLBI NIH HHS; HL117620-S1/HL/NHLBI NIH HHS; R01 HL092245/HL/NHLBI NIH HHS; R01 HL117620/HL/NHLBI NIH HHS; T32 GM077229/GM/NIGMS NIH HHS; TL1 TR000162/TR/NCATS NIH HHS; TL1 TR000162/TR/NCATS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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