Document Detail

Periungual and subungual pyogenic granuloma.
MedLine Citation:
PMID:  20545691     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Nail pyogenic granuloma (PG) is common, often seen as an urgent case, given the recent onset as a bleeding nodule. Nail PGs are due to different causes that act through different pathogenetic mechanisms and may be treated in several ways. Both causes and treatments of nail PG have never been classified.
OBJECTIVES: To classify nail PG according to the pathogenesis, describe the clinical and pathological features and provide guidelines for a correct diagnosis and treatment.
METHODS: A retrospective, observational study was performed reviewing epidemiological and clinical features of 58 cases of PG seen at our Departments in the last 5 years. A review of the literature was also carried out, using PubMed database and dermatological textbooks.
RESULTS: Nail PG is usually due to the following causes: drugs, local trauma and peripheral nerve injury. Histopathology shows similar features in every type of PG, irrespective of cause and location.
CONCLUSIONS: The localization of nail PG, the number of digits involved and clinical history help to identify the cause. When PG is single, especially if it involves the nail bed, histological examination is necessary to rule out malignant melanoma. Treatment must be chosen according to the underlying cause.
B M Piraccini; S Bellavista; C Misciali; A Tosti; D de Berker; B Richert
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The British journal of dermatology     Volume:  163     ISSN:  1365-2133     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-27     Completed Date:  2011-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  941-53     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. BJD © 2010 British Association of Dermatologists.
Department of Dermatology, University of Bologna, Bologna, Italy.
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MeSH Terms
Antineoplastic Agents / adverse effects
Granuloma, Pyogenic / epidemiology,  etiology,  pathology*,  therapy
Inflammation / complications
Keratolytic Agents / adverse effects
Middle Aged
Nail Diseases / epidemiology,  etiology,  pathology*,  therapy
Peripheral Nerves / injuries
Retrospective Studies
Wounds and Injuries / complications
Young Adult
Reg. No./Substance:
0/Antineoplastic Agents; 0/Keratolytic Agents

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