Document Detail

Periungual capillaroscopy in psoriasis.
MedLine Citation:
PMID:  22892767     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Nailfold capillaroscopy is a useful technique for evaluating changes in microcirculation.
OBJECTIVE: To investigate changes at nailfold capillaroscopy in psoriatic patients compared with controls.
METHODS: Nailfold capillaroscopy was performed in 46 psoriatic patients and 50 controls to assess microscopic morphological changes, capillary density and the presence of areas with devascularization.
RESULTS: Patients with psoriasis had lower capillary density (p=0.0005), increased avascular areas (p=0.0035) and an increased number of morphologically abnormal capillaries (coiled, p<0.0001) compared to controls. No association was found between capillary density and the duration of the disease (p = 0.92) or the extent of skin involvement, as measured by the psoriasis area and severity index (PASI) score (p = 0.59). The presence of avascular areas was more common in psoriatic individuals whose nails were affected by the condition (p = 0.047).
CONCLUSION: Patients with psoriasis have decreased capillary density and a greater presence of morphologically abnormal capillaries when compared to controls.
Camila Ferrari Ribeiro; Elisa Beatriz Dalledone Siqueira; Ana Paula Holler; Lincoln Fabrício; Thelma Larocca Skare
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anais brasileiros de dermatologia     Volume:  87     ISSN:  1806-4841     ISO Abbreviation:  An Bras Dermatol     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0067662     Medline TA:  An Bras Dermatol     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  550-3     Citation Subset:  IM    
Department of Dermatology, Evangelical University Hospital of Curitiba, Evangelical College of Paraná, Curitiba, PR, Brazil.
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